59743-88-3

Basic information

• Product Name: 10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5]cyclohepta[1,2-b]thiophene-4-ol
• Synonyms: 10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5]cyclohepta[1,2-b]thiophene-4-ol;4-HYDROXY-10-METHOXY-4-(1-METHYL-4-PIPERIDINYL)-4H-BENZO(4,5)CYCLOHEPTA(1,2-B)THIOPHENE;Einecs 261-907-7;4-Hydroxy-9,10-dehydro-10-Methoxy Ketotifen;10-Methoxy-4-(1-Methyl-4-piperidinyl)-4H-benzo[4,5]cyclohepta[1,2-b]thiophene-4-ol;Ketotifen FuMarate EP IMpurity B;10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5] cyclopheta[1.2-b]thiophene-4-ol;10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4,5]cyclohepta[1,2-b]thiophen-4-ol
• CAS NO: 59743-88-3
• Molecular Formula: C₂₀H₂₃NO₂S
• Molecular Weight: 341.46712
• EINECS: 261-907-7
• Product Categories: Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 59743-88-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 194-196℃ (ethanol )
• Boiling Point: 524°C at 760 mmHg
• Flash Point: 270.7°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 8.27E-12mmHg at 25°C
• Refractive Index: 1.652
• PKA: 12.91±0.40(Predicted)
• CAS DataBase Reference: 10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5]cyclohepta[1,2-b]thiophene-4-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5]cyclohepta[1,2-b]thiophene-4-ol(59743-88-3)
• EPA Substance Registry System: 10-methoxy-4-(1-methylpiperidin-4-yl)-4H-benzo[4.5]cyclohepta[1,2-b]thiophene-4-ol(59743-88-3)

Safety Data

• Hazardous Substances Data: 59743-88-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 59743-88-3 differently. You can refer to the following data:
1. Ketotifen impurity, used in separation of enantiomers of Ketotifen and its polar intermediate by isotachophoresis.
2. Ketotifen (K315100) impurity, used in separation of enantiomers of Ketotifen and its polar intermediate by isotachophoresis.

InChI:InChI=1/C20H23NO2S/c1-21-10-7-15(8-11-21)20(22)16-6-4-3-5-14(16)13-18(23-2)19-17(20)9-12-24-19/h3-6,9,12-13,15,22H,7-8,10-11H2,1-2H3

Upstream product

• 59743-84-9 10-methoxy-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one 
• 63463-36-5 (1-methyl-4-piperidyl)magnesium chloride 
• 5570-77-4 4-chloro-1-methylpiperidine 
• 34580-10-4 9,10-dibromo-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophene-4-one 
• 1622-55-5 9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-4-one 

Downstream Products

• 88456-70-6 4-(1-methyl-1-oxy-piperidin-4-ylidene)-4,9-dihydro-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one 
• 43076-12-6 9,10-Dihydro-4-(1-methyl-4-piperidyliden)-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-10-ol 
• 43076-17-1 4-(1-benzyl-piperidin-4-ylidene)-4,9-dihydro-benzo[4,5]cyclohepta[1,2-b]thiophen-10-one 
• 43076-16-0 4-(1-Methyl-4-piperidyliden)-4H-benzo<4,5>cyclohepta<1,2-b>thiophen-9,10-dion 
• 34580-13-7 Ketotifen 
• 34580-13-7 (+)-(R)-4-(1-methyl-4-piperidylidene)-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiopene-10-one 
• 34580-13-7 ketotifen 
• 126939-27-3 4-hydroxy-4-(1-methyl-4-piperidyl)-9,10-dihydro-4H-benzo<4,5>cyclohepta<1,2-b>thiopene-10-one 

Relevant articles and documents

4H-BENZOCYLOHEPTATHIOPHENES AND 9,10-DIHYDRO DERIVATIVES-SULFONIUM ANALOGUES OF PIZOTIFEN AND KETOTIFEN; CHIRALITY OF KETOTIFEN: SYNTHESIS OF THE 2-BROMO DERIVATIVE OF KETOTIFEN

Reaction of ketone IX with 4-tetrahydrothiopyranylmagnesium bromide and the following dehydration with thionyl chloride afforded the sulfide III which was transformed to the methiodide II (sulfonium analogue of pizotifen).Similar sequence starting from ketone XXIV and concluded by dehydration of the alcohol XX, cleavage of the enol ether, and by treatment with methyl iodide resulted in the formation of the sulfonium analogue of ketotifen (V).Three modified routes leading to ketotifen (IV) are being described.The chirality of ketotifen was proven by (1)H NMR spectrscopy with the help of,optically active NMR shift reagent.The resolution of racemic ketotifen (IV) was achieved by crystallization of salts with optically active O,O'-diacyltartaric acids and homogenous anantiomers were obtained.The X-ray crystallographic analysis of (+)-IV-O,O'-di(p-toluoyl)-(R)-tartrate led to the three- dimensional structure of the molecule of (+)-ketotifen which enabled to determine its absolute configuration to be (R).One of the products of bromination of the ketone IX, the following methanolysis and dehydrobromonation, identified as XXVII, was transformed by reaction with 1-methyl-4-piperidylmagnesium chloride, by the following acid-catalyzed dehydration, and cleavage of the enol ether to the 2-bromo derivative of ketotifen XXXIV. (R)(+)-Ketotifen (IV) was found to be the more active ketotifen enantiomer but the stereoselectivity of its action is only a partial one.The 2-bromo derivative of ketotifen (XXXIV) is much less active than ketotifen in the line antihistamine activity.

9-Bromo-or chloro-9,10-dihydro-10-dihydro-10-alkoxy-4H-benzo[4,5]cyclo-hepta[1,2-b]thiophen-4-ones

The present invention concerns a novel process for the production of known benzocycloheptathiophene derivatives of the formula: SPC1 Wherein R1 is hydrogen, chlorine, bromine or alkoxy, and R2 is alkyl. The compounds are useful as specific histaminolytics for use in the treatment of allergic conditions.