597542-74-0

Basic information

• Product Name: Cudraflavanone B
• Synonyms: Cudraflavanone B
• CAS NO: 597542-74-0
• Molecular Formula: C20H20O6
• Molecular Weight: 356.37
• Mol File: 597542-74-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Cudraflavanone B(CAS DataBase Reference)
• NIST Chemistry Reference: Cudraflavanone B(597542-74-0)
• EPA Substance Registry System: Cudraflavanone B(597542-74-0)

Safety Data

• Hazardous Substances Data: 597542-74-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Cudraflavanone B is used as an anticancer agent for its ability to inhibit the growth of cancer cells in vitro, making it a candidate for the development of novel anticancer drugs.
Used in Anti-Inflammatory Applications:
Cudraflavanone B is used as an anti-inflammatory agent due to its promising effects in reducing inflammation, which positions it as a potential treatment for various inflammatory diseases.
Used in Antioxidant Applications:
Cudraflavanone B is used as an antioxidant agent for its ability to combat oxidative stress, highlighting its potential in the development of treatments for conditions associated with oxidative damage.
Used in Food Industry:
Cudraflavanone B is used as a natural antioxidant in the food industry to extend the shelf life of products and improve their nutritional value.
Used in Cosmetic Industry:
Cudraflavanone B is used as an antioxidant in the cosmetic industry to protect the skin from oxidative stress and promote overall skin health.

Upstream product

• 780724-90-5 dimethylallyl diphosphate 
• 56486-94-3 (2S)-2-(2,4-dihydroxyphenyl)-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one 
• 358-72-5 dimethylallyl diphosphate 

Relevant articles and documents

Regio- and stereospecific prenylation of flavonoids by Sophora flavescens prenyltransferase

Prenylflavonoids are valuable natural products that are widely distributed in plants. They often possess divergent biological properties, including phytoestrogenic, anti-bacterial, anti-tumor, and anti-diabetic activities. The reaction catalyzed by prenyltransferases represents a Friedel-Crafts alkylation of the flavonoid skeleton in the biosynthesis of natural prenylflavonoids and often contributes to the structural diversity and biological activity of these compounds. However, only a few plant flavonoid prenyltransferases have been identified thus far, and these prenyltransferases exhibit strict substrate specificity and low catalytic efficiency. In this article, a flavonoid prenyltransferase from Sophora flavescens, SfFPT, has been identified that displays high catalytic efficiency with high regiospecificity acting on C-8 of structurally different types of flavonoid (i.e., flavanone, flavone, flavanonol, and dihydrochalcone, etc.). Furthermore, SfPFT exhibits strict stereospecificity for levorotatory flavanones to produce (2S)-prenylflavanones. This study is the first to demonstrate the substrate promiscuity and stereospecificity of a plant flavonoid prenyltransferase in vitro. Given its substrate promiscuity and high catalytic efficiency, SfFPT can be used as an environmentally friendly and efficient biological catalyst for the regio- and stereospecific prenylation of flavonoids to produce bioactive compounds for potential therapeutic applications. Copyright

Flavanone 8-dimethylallyltransferase in Sophora flavescens cell suspension cultures

Dimethylallyl diphosphate: naringenin 8-dimethylallyltransferase (EC 2.5.1) was characterized. The enzyme was enantiospecific for (-)-(2S)-naringenin and utilized 3,3-dimethylallyl diphosphate as sole prenyl donor. It required Mg2+ (optimum concentration, 10 mM), and has an optimum pH of 9-10. The apparent K(m) values for 3,3-dimethylallyl diphosphate and naringenin were 120 and 36 μM, respectively. The microsomal fraction prenylated several other flavanones at the C-8 position less effectively as compared with naringenin. Interestingly, when 2'-hydroxynaringenin was used as a prenyl acceptor, the 8-lavandulyl (sophoraflavanone G) and the 6-dimethylallyl derivatives were formed, together with the 8-dimethylallyl derivative, leachianone G. These results suggest that the 2'-hydroxy group of naringenin plays an important role for the formation of a lavandulyl group. (C) 2000 Elsevier Science Ltd.