56486-94-3

Usage

Uses

Used in Pharmaceutical Industry:
Steppogenin is used as an anti-inflammatory and analgesic agent for its ability to alleviate pain and reduce inflammation in various conditions.
Steppogenin is also used as an antitumor agent for its potential to inhibit tumor growth and progression, offering a promising therapeutic option for cancer treatment.
Further research on steppogenin's pharmacological properties and mechanisms of action is necessary to fully understand its therapeutic potential and optimize its use in the development of new drugs.

Upstream product

• 134955-33-2 2'-hydroxy-2,4,4',6'-tetrakis(methoxymethoxy)chalcone 
• 13709-06-3 2,4-bis(methoxymethoxy)benzaldehyde 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 

Relevant academic research and scientific papers

Flavonoids from Maclura tinctoria

Seven flavonoids, including two new natural products, were isolated from an ethanol extract of the bark of Maclura tinctoria (L.) Gaud. The new compounds are steppogenin 4'-O-β-D-glucoside and orobol 5,3'-di-O-methyl-8- C-glucoside. Orobol, steppogenin, aromadendrin, dihydromorin and orobol 7-O- β-D-glucoside were also isolated.

Synthesis and evaluation of 2′,4′,6′-trihydroxychalcones as a new class of tyrosinase inhibitors

In this study, we synthesized a series of hydroxychalcones and examined their tyrosinase inhibitory activity. The results showed that 2′,4′,6′-trihydroxychalcone (1), 2,2′,3,4′,6′-pentahydroxychalcone (4), 2′,3,4,4′,5,6′-hexahydroxychalcone (5), 2′,4′,6′-trihydroxy- 3,4-dimethoxychalcone (9) and 2,2′,4,4′,6′-pentahydroxychalcone (15) exhibited high inhibitory effects on tyrosinase with respect to l-tyrosine as a substrate. By the structure-activity relationship study, it was suggested that the 2′,4′,6′-trihydroxyl substructure in the chalcone skeleton were efficacious for the inhibition of tyrosinase activity. And also, the catechol structure on B-ring of chalcones was not advantageous for the inhibitory potency. Furthermore, 15 (IC50 = 1 μM) was found to show the highest activity out of a set of 15 hydroxychalcones, even better than both 2,2′,4,4′-tetrahydroxychalcone (13, IC50 = 5 μM) and kojic acid (16, IC50 = 12 μM), which were known as potent tyrosinase inhibitors. Kinetic study revealed that 15 acts as a competitive inhibitor of tyrosinase with Ki value of 3.1 μM.

Aromatase inhibitors from Broussonetia papyrifera

A composition and method of cancer treatment is disclosed. The composition and method utilized the extract of B. papyrifera, or compounds included therein having aromatase inhibition properties, as active cancer chemopreventative and treating agents in mammals, including humans.