597562-79-3

Basic information

• Product Name: 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE
• Synonyms: 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE;1,2,3,4-Tetrahydro-quinoline-7-carboxylicacidmet;Methyl 1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride;1,2,3,4-Tetrahydro-quinoline-7-carboxylic acid methyl ester;7-Quinolinecarboxylic acid, 1,2,3,4-tetrahydro-, methyl ester
• CAS NO: 597562-79-3
• Molecular Formula: C₁₁H₁₃NO₂
• Molecular Weight: 227.68736
• Mol File: 597562-79-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(597562-79-3)
• EPA Substance Registry System: 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE(597562-79-3)

Safety Data

• Hazardous Substances Data: 597562-79-3(Hazardous Substances Data)

Usage

General Description

1,2,3,4-tetrahydro-quinoline-7-carboxylic acid methyl ester hydrochloride is a chemical compound with the molecular formula C12H15NO2Cl. It is a salt form of the carboxylic acid methyl ester and is commonly used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical products. 1,2,3,4-TETRAHYDRO-QUINOLINE-7-CARBOXYLIC ACID METHYL ESTER HYDROCHLORIDE is known for its potential biological activities and is being studied for its potential use in the treatment of various diseases. It is also used as a building block in organic synthesis and chemical research. Additionally, it has potential applications in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C11H13NO2.ClH/c1-14-11(13)9-5-4-8-3-2-6-12-10(8)7-9;/h4-5,7,12H,2-3,6H2,1H3;1H

Upstream product

• 64-17-5 ethanol 
• 51552-68-2 quinoline-7-carboxylic acid methyl ester 

Downstream Products

• 1034775-95-5 (4-{[1-(2-methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carbonyl]-amino}-phenyl)-acetic acid 
• 1030847-11-0 (1-phenyl-1,2,3,4-tetrahydroquinolin-7-yl)methanol 
• 1030846-96-8 methyl 1-phenyl-1,2,3,4-tetrahydroquinoline-7-carboxylate 
• 1034776-74-3 1-(2-methoxy-5-methyl-benzenesulfonyl)-1,2,3,4-tetrahydro-quinoline-7-carboxylic acid methyl ester 

Relevant articles and documents

Ni0/Niδ+ Synergistic Catalysis on a Nanosized Ni Surface for Simultaneous Formation of C-C and C-N Bonds

Simultaneous formation of C-C/C-N bonds provides insight into the bottom-up synthesis of N-heterocycles. This work reports Ni0/Niδ+ synergistic catalysis on the surface of Ni nanoparticles for the highly efficient one-pot formation of C-C/C-N bonds, affording 1,2,3,4-tetrahydroquinoline and its derivatives from 2-amino benzyl alcohol and ethanol without any addition of liquor base or external hydrogen. Ni0/Niδ+ synergistic catalysis has been achieved by regulating the Ni particle size or activating the Ni surface with O2. In the dehydrogenation of -CH2-OH to -CH=O, the formation of C==C and C=N bonds via concurrent cross-condensation, and the transformation of C=C/C=N to C-C/C-N via hydrogen transfer, ethanol dehydrogenation has been found to be the rate-determining step. Reducing the Ni particle size effectively increases the number of surface Niδ+ sites, which accelerates catalytic dehydrogenation through synergistic catalysis between surface Niδ+ and Ni0 sites. The number of surface Niδ+ sites can be further increased by appropriately activating the Ni surface with O2

SULFONAMIDE DERIVATIVES

The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R1, R2, R3, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.