5976-67-0

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxyestradiol-3-Methyl Ether is used as an anticancer agent for its antiproliferative and antiangiogenic properties. It targets various cancer cells by inhibiting their growth and the formation of new blood vessels that supply nutrients to the tumor, thus limiting tumor progression and metastasis.
Additionally, due to its estrogenic properties, it may have potential applications in treating conditions related to estrogen deficiency or imbalance, such as menopausal symptoms or osteoporosis. However, further research is needed to explore these potential uses and ensure safety and efficacy.

InChI:InChI=1/C15H11BrN2O4S/c1-2-3-18-14(20)9(13(19)17-15(18)23)4-8-5-11-12(6-10(8)16)22-7-21-11/h2,4-6H,1,3,7H2,(H,17,19,23)/b9-4-

Upstream product

• 4735-40-4 (+/-)-13β-Methyl-2,3-dimethoxygona-1,3,5(10),8,14-pentaen-17-on 
• 4735-42-6 (+/-)-2,3-Dimethoxy-oestra-1,3,5⁽¹⁰⁾,8-tetraen-17-on 
• 186581-53-3 diazomethane 
• 362-05-0 2-Hydroxyestradiol 
• 23463-05-0 estra-1,3,5(10)-triene-2,3,17β-triol-17-acetate 
• 52717-98-3 (13S,17S)-3-hydroxy-2-methoxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-17-yl acetate 
• 362-07-2 2-Methoxyestradiol 
• 74-88-4 methyl iodide 
• 52717-99-4 2-Hydroxy-oestradiol-3-methylaether-17-acetat 
• 5976-70-5 17β-Acetoxy-2,3-dimethoxy-oestra-1,3,5(10)-trien 
• 77-78-1 dimethyl sulfate 
• 5976-65-8 2-Hydroxy-Estradiol-3-methyl ether 

Downstream Products

• 362-06-1 2-hydroxyestrone 
• 362-06-1 (+/-)-2,3-Dihydroxy-oestra-1,3,5⁽¹⁰⁾-trien-17-on 

Relevant academic research and scientific papers

Synthesis and antitumor activities of 3-modified 2-methoxyestradiol analogs

The syntheses of 2-methoxyestradiol analogs with modifications at the 3-position are described. The analogs were assessed for their antiproliferative, antiangiogenic, and estrogenic activities. Several lead substituents were identified with similar or imp

Methylation of catechol estrogen with diazomethane

Dynamic aspects of methylation of catechol estrogen with diazomethane were investigated by means of thin-layer chromatography. The methylation rate of the hydroxyl group at the C-3 position was almost the same as that of the C-2 hydroxyl group in the reaction of 2-hydroxyestrogen, and 2-3 times that of the C-4 hydroxyl group in the reaction of 4-hydroxyestrogen. In these experiments, the maximum yields of 2-methoxyestrone, 2-hydroxyestrone 3-methyl ether, 4-methoxyesterone and 4-hydroxyesterone 3-methyl ether were 32, 39, 13, and 70%, respectively. In addition, demethylation of catechol estrogen dimethyl ethers with boron tribromide and synthesis of 4-hydroxyestrone monomethyl ethers are described.