23463-05-0

Upstream product

• 26362-44-7 2-acetyl-estra-1,3,5(10)-triene-3,17β-diol 17-acetate 
• 4601-35-8 2α,17β-diacetoxy-estr-4-en-3-one 
• 1425-10-1 19-nortestosterone acetate 
• 50-28-2 estradiol 
• 13731-44-7 3-Oxo-4β,5β-oxido-17β-acetoxy-oestran 
• 14531-74-9 17β-acetoxy-2α-hydroxy-estr-4-en-3-one 
• 64-19-7 acetic acid 

Downstream Products

• 362-05-0 2-Hydroxyestradiol 
• 5976-67-0 17beta-Estradiol 2,3-dimethyl ether 
• 116282-36-1 2-hydroxyestrone 2,3-dibenzoate 
• 362-06-1 2-hydroxyestrone 

Relevant academic research and scientific papers

A NEW SYNTHETIC ROUTE TO 2-HYDROXYL STEROIDAL ESTROGENS VIA ACETYLATION AND DAKIN OXIDATION

This paper describes a new two-step synthetic route to 2-hydroxy estrogens from either estrone or estradiol, via 2-acetylation followed by Dakin oxidation.This approach is characterized by its simplicity and excellence of yield.

Glycosides of catechol estrogens

There are described novel glycosides of catechol estrogen, a method of preparing the same, and a medicament comprising one of the glycosides as an active ingredient. The glycosides are shown by the formula of STR1 wherein X is carbonyl group or STR2 R10 is hydroxyl group or glycosyloxy group, and R2 is a hydrogen atom or ethynyl group; R11 is a hydrogen atom, hydroxyl group, or glycosyloxy group; R12 is hydroxyl group or glycosyloxy group; and R13 is hydroxyl group or glycosyloxy group, in which glycosyloxy group is selected from the group consisting of glucosyloxy, galactosyloxy, mannosyloxy, arabinosyloxy, ribosyloxy, xylosyloxy, fructosyloxy, rhamnosyloxy, fucosyloxy, maltosyloxy, cellobiosyloxy, lactosyloxy, sucrosyloxy, maltotriosyloxy, maltotetraosyloxy, maltopentaosyloxy, maltohexaosyloxy, maltoheptaosyloxy, and sialosyloxy, and in this case, at least one of R10, R11, R12, and R13 is glycosyloxy group as defined above.