59793-76-9

Basic information

• Product Name: 4-BROMOBENZOPHENONE ETHYLENE KETAL
• Synonyms: 4-BROMOBENZOPHENONE ETHYLENE KETAL
• CAS NO: 59793-76-9
• Molecular Formula: C₁₅H₁₃BrO₂
• Molecular Weight: 305.17
• Mol File: 59793-76-9.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 378.3°C at 760 mmHg
• Flash Point: 164.8°C
• Appearance: /
• Density: 1.427g/cm³
• Vapor Pressure: 1.38E-05mmHg at 25°C
• Refractive Index: 1.603
• CAS DataBase Reference: 4-BROMOBENZOPHENONE ETHYLENE KETAL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZOPHENONE ETHYLENE KETAL(59793-76-9)
• EPA Substance Registry System: 4-BROMOBENZOPHENONE ETHYLENE KETAL(59793-76-9)

Safety Data

• Hazardous Substances Data: 59793-76-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H13BrO2/c16-14-8-6-13(7-9-14)15(17-10-11-18-15)12-4-2-1-3-5-12/h1-9H,10-11H2

Upstream product

• 90-90-4 (4-bromophenyl)(phenyl)methanone 
• 107-21-1 ethylene glycol 

Downstream Products

• 76509-27-8 4-(p-(N,N-dimethylamino)benzoyl)bromobenzophenone ethylene acetal 
• 1374968-23-6 1'-(4-benzoylphenyl)-3'-O-(2-cyanoethoxy(diisopropylamino)phosphanyl)-5'-O-(dimethoxytrityl)-1',2'-dideoxyribofuranose 
• 1374968-22-5 1'-(4-benzoylphenyl)-5'-O-(dimethoxytrityl)-1',2'-dideoxyribofuranose 
• 1374968-18-9 1'-(4-benzoylphenyl)-1',2'-dideoxyribofuranose 
• 1374968-21-4 1'-(4-benzoylphenyl)-1',2'-dideoxyribofuranose 
• 73557-71-8 p-(α-fluoro-β,β,β-trifluoroethyl)benzophenone ethylene ketal 
• 73557-72-9 p-(α-fluoro-β,β,β-trifluoroethyl)benzophenone 

Relevant articles and documents

An Aromatic Hydroxyamide Attenuates Multiresistant Staphylococcus aureus Toxin Expression

Methicillin-resistant Staphylococcus aureus (MRSA) causes severe infections with only few effective antibiotic therapies currently available. To approach this challenge, chemical entities with a novel and resistance-free mode of action are desperately needed. Here, we introduce a new hydroxyamide compound that effectively reduces the expression of devastating toxins in various S. aureus and MRSA strains. The molecular mechanism was investigated by transcriptome analysis as well as by affinity-based protein profiling. Down-regulation of several pathogenesis associated genes suggested the inhibition of a central virulence-related pathway. Mass spectrometry-based chemical proteomics revealed putative molecular targets. Systemic treatment with the hydroxyamide showed significant reduction of abscess sizes in a MRSA mouse skin infection model. The absence of resistance development in vitro further underlines the finding that targeting virulence could lead to prolonged therapeutic options in comparison to antibiotics that directly address bacterial survival. Disarming MRSA: A new hydroxyamide compound effectively reduces the expression of devastating toxins in various S. aureus and MRSA strains. The molecular mechanism was investigated by transcriptome analysis, as well as by affinity-based protein profiling. Systemic treatment with the hydroxyamide showed significant reduction of abscess sizes in an MRSA mouse skin infection model.

Stereoselective synthesis of photoreactive peptidomimetic γ-secretase inhibitors

The first asymmetric synthesis of novel, potent photoreactive γ-secretase inhibitors 2 and 3 has been accomplished. Two Stereoselective methods for the preparation of lactone 9 are described. Protected benzophenone intermediate 19 is prepared via an aldol-elimination reaction followed by a PtO2-catalyzed asymmetric hydrogenation. Two routes leading from 19 to compounds 2 and 3 are evaluated. The application of 3 as an activity-based probe has been demonstrated by localizing γ-secretase activity in the plasma membrane of intact cells.

Benzophenone boronic acid photoaffinity labeling of subtilisin CMMs to probe altered specificity

A transition state analogue inhibitor, boronic acid benzophenone (BBP) photoprobe, was used to study the differences in the topology of the S1 pocket of chemically modified mutant enzymes (CMMs). The BBP proved to be an effective competitive in