59797-01-2Relevant academic research and scientific papers
Convenient selective synthesis of substituted pyrido[2,3-d]pyrimidones and annulated derivatives
Hamama, Wafaa S.,Ismail, Mohamed A.,Al-Saman, HanA'A A.,Zoorob, Hanafi H.
, p. 104 - 110 (2007)
The reaction of 6-aminouracil (1) with the appropriate α,β- unsaturated ketones, gave the corresponding pyrido[2,3-d]pyrimidin-2,4-diones 3, 6, 8 and 10, respectively. Treatment of 1 with salicylaldehyde, 6-carboethoxy-3,5-diphenyl-2-cyclohexenone (13) or
Synthesis of pyrido[2,3-d]pyrimidines from 6-amino-1,3-dimethyluracil and aldehydes
Azev,Ermakova,Gibor,Bakulev,Ezhikova,Kodess
, p. 1784 - 1787 (2016/02/03)
6-Amino-1,3-dimethyluracil reacted with aliphatic aldehydes on heating in formic acid to give mixtures of 1,3,7,9-tetramethylpyrido[2,3-d: 6,5-d']dipyrimidine-2,4,6,8(1H,3H,7H,9H)-tetraone and the corresponding 5,6-dialkyl-1,3-dimethylpyrido[2,3-d]pyrimid
Efficient one-pot synthesis of substituted pyrido[2,3-d]pyrimidines from vinamidinium and chloropropeniminium salts
Ayed, Mohamed Adnen Hadj,Gmiza, Thouraya,Khiari, Jamel Eddine,Hassine, Bechir Ben
supporting information; experimental part, p. 1824 - 1831 (2012/04/23)
A novel and efficient one-pot preparation of 6-substituted pyrido-[2,3-d]pyrimidines by cyclocondensation of 6-amino-1,3-dimethyluracil with symmetrical vinamidinium salts under basic conditions has been developed. Regioselectivity was observed with an unsymmetrical chloropropeniminium salt. Copyright Taylor & Francis Group, LLC.
SYNTHESIS OF PYRIDOPYRIMIDINE-2,4-DIONES FROM PYRIMIDO-1,2,4-TRIAZINE-6,8-DIONES BY REVERSED AZADIENE SYNTHESIS
Shorshnev, S. V.,Esipov, S. E.,Chernyshev, A. I.,Pozharskii, A. F.,Kuz'menko, V. V.,Gulevskaya, A. V.
, p. 191 - 200 (2007/10/02)
It as shown that pyrimido-1,2,4-triazine-6,8-diones enter the reversed azadiene synthesis reaction with ketones and vinyl ethyl ether in the presence of diethylamine or boron trifluoride etherate, and also with enamines.As a result of the reaction, pyridopyrimidine-2,4-diones are formed in good yield.Pyrimido-1,2,4-triazine-5,7-diones do not undergo such reactions with acetone.The reasons for the unique behavior of the isomeric pyrimidotriazinediones in the reaction with acetone are discussed.
