59820-90-5

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromo-4,5-ethylenedioxyacetophenone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex organic compounds and heterocycles, which are essential in developing new drugs and improving existing ones.
Used in Organic Chemistry:
In the field of organic chemistry, 2-Bromo-4,5-ethylenedioxyacetophenone is utilized as a reagent in the synthesis of natural products, contributing to the development of novel compounds with potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Used in Medicinal Chemistry:
2-Bromo-4,5-ethylenedioxyacetophenone is employed as a building block in the design and synthesis of new medicinal compounds, leveraging its unique chemical properties to create innovative therapeutic agents that address unmet medical needs.

Upstream product

• 75-36-5 acetyl chloride 
• 52287-51-1 6-bromo-1,4-benzodioxane 
• 25812-80-0 6,7-dibromo-2,3-dihydrobenzo[b][1,4]dioxine 
• 69464-32-0 6-bromo-7-chloro-2,3-dihydro-benzo[1,4]dioxine 
• 493-09-4 benzo-1,4-dioxane 

Relevant academic research and scientific papers

o-Acylbenzonitriles: Synthesis and Heterocyclization under Acid Hydrolysis of the Cyano Group

2-Cyanobenzophenones were synthesized by reaction of 2-bromobenzophenones with copper(I) cyanide in DMF, and their transformations involving acid hydrolysis of the cyano group were studied. Reactions of o-benzoylbenzonitriles with trifluoroacetic acid in

Process development of the synthetic route to sulamserod hydrochloride

Sulamserod hydrochloride is a potent S-HT4 receptor antagonist and was a clinical candidate for the treatment of gastrointestinal disorders. Process development of the fairly long synthetic route (12 linear, 14 overall steps) was undertaken. Process improvements were highlighted by aromatic chlorination choices in making dichlorobenzodioxan 2 and acetylaminochloroketone 7, a transfer hydrogenation reducing a nitro group and simultaneous aromatic dechlorination without ketone reduction to give aminoketone 5, and use of the potential mutagenic iodosulfonamide 14 to make quaternary salt 11. The chemistry was scaled-up into pilot plant reactor vessels to produce multikilogram amounts of Sulamserod hydrochloride suitable for drug development.