59832-41-6Relevant academic research and scientific papers
Synthesis of chiral tetrahydrofurans via catalytic asymmetric [3 + 2] cycloaddition of heterosubstituted alkenes with oxiranes
Yuan, Xiao,Lin, Lili,Chen, Weiliang,Wu, Wangbin,Liu, Xiaohua,Feng, Xiaoming
, p. 1237 - 1243 (2016/02/19)
An efficient diastereo- and enantioselective [3 + 2] cycloaddition of heterosubstituted alkenes with oxiranes via selective C-C bond cleavage of epoxides has been developed. The reaction was catalyzed by a chiral N,N′-dioxide/Ni(II) catalyst, and a variety of chiral highly substituted tetrahydrofurans were obtained in up to 99% yield, 92/8 dr, and 99% ee.
