59840-70-9

Upstream product

• 13735-81-4 1-styrenyloxytrimethylsilane 
• 817-87-8 ethyl azidocarbonate 
• 5468-37-1 2-aminoacetophenone hydrochloride 
• 541-41-3 chloroformic acid ethyl ester 
• 532-27-4 1-chloroacetophenone 

Downstream Products

• 109355-73-9 ethyl 2-hydroxy-2-phenylethylcarbamate 
• 144372-49-6 (2R)-N-ethoxycarbonyl-2-phenyl-2-hydroxyethylamine 
• 149286-08-8 Acetic acid (S)-2-ethoxycarbonylamino-1-phenyl-ethyl ester 
• 2549-14-6 (R)-2-Amino-1-phenylethanol 
• 56613-81-1 (S)-2-Amino-1-phenyl-1-ethanol 
• 83362-01-0 2-amino-3-cyano-1-ethoxycarbonyl-4-phenylpyrrole 

Relevant academic research and scientific papers

Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.

A NOVEL SYNTHESIS OF N-SUBSTITUTED α-AMINO KETONES

The thermolysis of ethyl azidoformate in enol trimethylsilyl ethers, followed by silica gel treatment, offers a new route to N-ethoxycarbonyl α-amino ketones.