Baker's Yeast Reduction of α-(Acylamino)acetophenones and Lipase Catalyzed Resolution of 2-Acylamino-1-arylethanols

DOI: 10.1246/bcsj.66.1216

Source and publish data:

Bulletin of the Chemical Society of Japan p. 1216 - 1221 (1993)

Update date:2022-08-05

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Authors:

Izumi, Taeko

Fukaya, Katsumi

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Article abstract of DOI:10.1246/bcsj.66.1216

Enzymatic reduction of α-acylaminoacetophenones with fermenting baker's yeast afforded optically active (R)-2-acylamino-1-arylethanols.Furthermore, lipase-catalyzed resolution of the 2-acylamino-1-arylethanols using vinyl acetate as an acyl donor resulted in the formation of (S)-1-acetoxy-2-acylamino-1-arylethanols and (R)-2-acylamino-1-arylethanols.

Full text of DOI:10.1246/bcsj.66.1216

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