59843-49-1

Usage

Uses

Used in Scientific Research:
3-(2-Methylphenyl)-1H-pyrazole is used as a research compound for exploring its chemical structure and properties, as well as its potential applications in various fields of science.
Used in Drug Development:
3-(2-Methylphenyl)-1H-pyrazole is used as a lead compound in drug development due to its potential pharmacological properties, particularly as an inhibitor of certain enzymes, which may contribute to the discovery of new therapeutic agents.
Used in Medicinal Chemistry Studies:
In the field of medicinal chemistry, 3-(2-Methylphenyl)-1H-pyrazole is utilized as a starting point for the synthesis of novel compounds with potential therapeutic applications, leveraging its unique chemical structure and properties to design and optimize new molecules for various medical uses.

Upstream product

• 1072-63-5 1-vinylimidazole 
• 529-20-4 2-methylphenyl aldehyde 
• 35629-84-6 N'-(2-methylbenzylidene)-4-methylbenzenesulfonohydrazide 
• 75-20-7 calcium carbide 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 577-16-2 2-Methylacetophenone 

Downstream Products

• 59843-50-4 N,N-dimethyl-2-(3-o-tolyl-pyrazol-1-yl)-propionamide 
• 59843-51-5 N,N-dimethyl-2-(5-o-tolyl-pyrazol-1-yl)-propionamide 
• 59844-45-0 2,N,N-trimethyl-2-(3-o-tolyl-pyrazol-1-yl)-propionamide 
• 59844-08-5 N,N-dimethyl-2-(3-o-tolyl-pyrazol-1-yl)-butyramide 
• 1335210-51-9 C₂₄H₁₈N₂ 

Relevant academic research and scientific papers

ORGANIC ELECTROLUMINESCENT MATERIALS AND DEVICES

A compound having a structure of the formula Ir(LA)(LB), in which LA is a bidentate, tridentate, tetradentate, pentadentate, or hexadentate ligand and LB is a monodentate, bidentate, tridentate, or tetradentate ligand, or not present, and where the total denticity of LA plus LB is 6, and LA includes at least one structure of Formula I: is disclosed as a useful phosphorescent emitter compound.

Calcium carbide as the acetylide source: Transition-metal-free synthesis of substituted pyrazoles via [1,5]-sigmatropic rearrangements

Under transition-metal-free conditions, calcium carbide was used as the acetylide source to react with a wide range of N-tosylhydrazones derived from aldehydes or ketones, affording various substituted pyrazoles in good yields with high regioselectivities. The transformations go through [3 + 2] cycloadditions followed by [1,5]-sigmatropic rearrangements, which are supported by deuterium-labeling experiments.

A novel one-pot method for the preparation of pyrazoles by 1,3-dipolar cycloadditions of diazo compounds generated in situ

A convenient one-pot procedure for the preparation of pyrazoles by 1,3-dipolar cycloaddition of diazo compounds generated in situ has been developed. Diazo compounds derived from aldehydes were reacted with terminal alkynes to furnish regioselectively 3,5-disubstituted pyrazoles. Furthermore, the reaction of N-vinylimidazole and diazo compounds derived from aldehydes gave exclusively 3-substituted pyrazoles in a one-pot process.