59849-52-4

Upstream product

• 61081-27-4 2-((2-fluorophenyl)thio)acetonitrile 
• 348-54-9 2-Fluoroaniline 
• 2557-78-0 2-fluorothiophenol 
• 348-52-7 1-Fluoro-2-iodobenzene 
• 1624363-23-0 3-azido-2-methylbut-3-en-2-ol 

Downstream Products

• 1384585-77-6 C₁₂H₁₀FNO₂S₂ 
• 1384586-01-9 2-(2-fluorophenylsulfonyl)-2-phenylacetonitrile 
• 1041166-94-2 3-(4-chlorophenyl)-4H-1,4-benzothiazine 1,1-dioxide 
• 76148-83-9 3-(4-methoxyphenyl)-4H-1,4-benzothiazine 1,1-dioxide 
• 1384585-81-2 C₁₅H₁₄FNO₃S 
• 1384585-82-3 C₁₅H₁₄FNO₂S 
• 1384585-73-2 C₁₄H₁₁ClFNO₂S 
• 1384585-69-6 C₁₅H₁₄FNO₃S 
• 1384585-83-4 C₁₈H₁₄FNO₂S 
• 1384585-74-3 C₁₅H₁₄FNO₂S₂ 
• 1384585-71-0 C₁₅H₁₁F₄NO₂S 
• 1384585-75-4 C₁₅H₁₁FN₂O₂S 
• 1384585-70-9 C₁₆H₁₄FNO₃S 
• 1384585-80-1 C₁₆H₁₄FNO₃S 

Relevant academic research and scientific papers

Direct access to 1,4-benzothiazine 4,4-dioxides and 4-oxides via a domino reaction

The domino reactions of 2-fluoro benzensulfonyl acetonitrile and α-chloro oximes in the presence of Cs2CO3 in aprotic high boiling point solvents have been achieved to provide isoxazole?fused 4H-1,4-benzothiazine-4,4-dioxides via an

Photoinduced synthesis of 2-sulfonylacetonitriles with the insertion of sulfur dioxide under ultraviolet irradiation

Metal-free insertion of sulfur dioxide with aryl iodides and 3-azido-2-methylbut-3-en-2-ol under ultraviolet irradiation at room temperature is achieved, giving rise to 2-(arylsulfonyl)acetonitriles in moderate to good yields. Alkyl iodide is also workable under these conditions. This transformation proceeds smoothly under mild conditions with a broad substrate scope. Various functional groups are compatible including amino, ester, halo, and trifluoromethyl groups. No metal catalyst or additive is needed during the reaction process. Mechanistic studies show that under ultraviolet irradiation, an aryl radical is generated in situ from aryl iodide, which undergoes subsequent sulfonylation via the insertion of sulfur dioxide leading to arylsulfonyl radical intermediates. Then the arylsulfonyl radical reacts with 3-azido-2-methylbut-3-en-2-ol giving rise to the corresponding 2-(arylsulfonyl)acetonitrile.

3-SUBSTITUTED 2-AMINO-INDOLE DERIVATIVES

The present invention provides compounds of formula (I) (Formula (I)) and pharmaceutically acceptable salts thereof, wherein Q, X% X4,X5 X6, X7,R1, R2, R3 and R8 are as defined in the specification, processes for the preparation of such compounds, pharmaceutical compositions containing them and the use of such compounds in therapy.

Use of (Z)-β-(2-fluorobenzenesulfonyl)vinylamines as novel synthons in the synthesis of 1,4-benzothiazine derivatives

A novel synthetic route for arylated 1,4-benzothiazine derivatives has been developed. This method utilizes a key intramolecular nucleophilic aromatic substitution step of the corresponding (Z) - (2-fluorobenzenesulfonyl)vinylamine intermediate to construct the benzothiazine ring. A wide range of aryl and heteroaryl substituent groups can be installed from commercial boronic acids. Both mono- and diarylated products have been synthesized in good yields and with good functional group tolerance. Georg Thieme Verlag Stuttgart · New York.