59850-50-9Relevant academic research and scientific papers
Preparation method of (2R, 3R)-3-methyl-3-phenylalanine
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Paragraph 0009; 0025; 0030, (2021/06/23)
The invention relates to a preparation method of (2R, 3R)-3-methyl-3-phenylalanine. The technical problems that an existing preparation method is long in route, expensive in used reagent, incapable of achieving large-scale production and the like are mainly solved. According to the technical scheme, the preparation method of the (2R, 3R)-3-methyl-3-phenylalanine comprises the following steps: condensing 2-acetamidomalonic acid diethyl ester and 1-bromoethyl benzene under the action of alkali to obtain 2-acetamido-2-(1-phenylethyl) malonic acid diethyl ester; heating and hydrolyzing in concentrated hydrochloric acid, concentrating and crystallizing to obtain erythro 3-methyl-3-phenylalanine; then performing acylation to obtain the erythro 2-acetamido-3-methyl 3-phenylalanine; splitting under the action of acetamido transferase, and obtaining (2R, 3R)-2-acetamido-3-methyl 3-phenylalanine; and finally, heating and hydrolyzing by using hydrochloric acid to obtain the product (2R, 3R)-3-methyl-3-phenylalanine (hydrochloride).
Site-Selective γ-C(sp3)?H and γ-C(sp2)?H Arylation of Free Amino Esters Promoted by a Catalytic Transient Directing Group
Lin, Hua,Wang, Chao,Bannister, Thomas D.,Kamenecka, Theodore M.
supporting information, p. 9535 - 9541 (2018/07/14)
The first selective PdII-catalysed γ-C(sp3)?H and γ-C(sp2)?H arylation of free amino esters using a commercially available catalytic transient directing group. A variety of free amino esters, including α-amino esters and β-amino esters, amino monoesters and amino bis-esters, are shown to react with a diverse range of simple aryl and heteroaryl iodide reagents.
Indium(III)-catalyzed addition of diethyl acetamidomalonate to terminal alkynes: An efficient approach to β-branched α-amino acids
Angell, Paul,Blazecka, Peter G.,Lovdahl, Mark,Zhang, Ji
, p. 6606 - 6609 (2008/02/10)
(Chemical Equation Presented) The indium(III)-catalyzed Markovnikov addition of active methylene compounds to terminal alkynes has been expanded further to include diethyl acetamidomalonate. This reaction has been studied, and a practical approach to β-branched α-amino acids was developed.
