80997-87-1

Usage

Chemical Properties

White powder to beige powder

InChI:InChI=1/C10H13NO2.ClH/c1-7(9(11)10(12)13)8-5-3-2-4-6-8;/h2-7,9H,11H2,1H3,(H,12,13);1H

Upstream product

• 585-71-7 (1-bromoethyl)benzne 
• 1068-90-2 2-acetylaminomalonic acid diethyl ester 
• 59850-50-9 diethyl (acetylamino)(1-phenylethyl)malonate 
• 949887-00-7 diethyl (acetylamino)(1-phenylvinyl)malonate 
• 536-74-3 phenylacetylene 

Relevant academic research and scientific papers

Preparation method of (2R, 3R)-3-methyl-3-phenylalanine

The invention relates to a preparation method of (2R, 3R)-3-methyl-3-phenylalanine. The technical problems that an existing preparation method is long in route, expensive in used reagent, incapable of achieving large-scale production and the like are mainly solved. According to the technical scheme, the preparation method of the (2R, 3R)-3-methyl-3-phenylalanine comprises the following steps: condensing 2-acetamidomalonic acid diethyl ester and 1-bromoethyl benzene under the action of alkali to obtain 2-acetamido-2-(1-phenylethyl) malonic acid diethyl ester; heating and hydrolyzing in concentrated hydrochloric acid, concentrating and crystallizing to obtain erythro 3-methyl-3-phenylalanine; then performing acylation to obtain the erythro 2-acetamido-3-methyl 3-phenylalanine; splitting under the action of acetamido transferase, and obtaining (2R, 3R)-2-acetamido-3-methyl 3-phenylalanine; and finally, heating and hydrolyzing by using hydrochloric acid to obtain the product (2R, 3R)-3-methyl-3-phenylalanine (hydrochloride).

Indium(III)-catalyzed addition of diethyl acetamidomalonate to terminal alkynes: An efficient approach to β-branched α-amino acids

(Chemical Equation Presented) The indium(III)-catalyzed Markovnikov addition of active methylene compounds to terminal alkynes has been expanded further to include diethyl acetamidomalonate. This reaction has been studied, and a practical approach to β-branched α-amino acids was developed.

Synthesis and antitumor activity of platinum(II) complexes containing substituted ethylenediamine ligands

The synthesis of substituted ethylenediamines, their reactions with K2PtCl4 to give the dichloroplatinum(II) complexes, and the exchange of the chloro ligands for other leaving groups are described.The new compounds have been tested as antitumor agents both in vitro using the hormone independent human mammary carcinoma cell line MDA-MB 231 as well as in vivo using the lymphocytic P388 leukemia of the CD2F1-mouse.In the P388 test, 53 of the 55 tested complexes fulfill the minimum activity of 125percent T/C required for a substance to be active.