59864-01-6

Usage

Uses

Used in Pharmaceutical Industry:
α-Benzoyl-α-bromoacetic acid methyl ester is used as a reagent in the synthesis of various types of molecules for the pharmaceutical industry. Its ability to facilitate the formation of carbon-carbon bonds makes it a valuable component in the development of new drugs and medicinal compounds.
Used in Organic Synthesis:
α-Benzoyl-α-bromoacetic acid methyl ester is used as a reagent in organic synthesis for the formation of carbon-carbon bonds. This property is essential in creating complex organic molecules and contributes to the advancement of chemical research and development.
Used in Production of Agrochemicals:
α-Benzoyl-α-bromoacetic acid methyl ester is used as a key intermediate in the production of agrochemicals. Its role in the synthesis of various organic compounds makes it a crucial component in the development of agricultural chemicals and pesticides.
Used in Production of Other Valuable Organic Compounds:
α-Benzoyl-α-bromoacetic acid methyl ester is used as a key intermediate in the production of other valuable organic compounds. Its versatility in organic synthesis allows for the creation of a wide range of chemical products with various applications across different industries.

Upstream product

• 103-26-4 Methyl cinnamate 
• 90841-69-3 methyl 2-bromo-3-hydroxy-3-phenylpropanoate 
• 614-27-7 methyl 3-oxo-3-phenylpropionate 

Downstream Products

• 893652-36-3 methyl 2-amino-4-phenyl-1,3-thiazole-5-carboxylate 
• 67139-60-0 methyl 5-(4-methoxyphenyl)-2-phenylthiophene-3-carboxylate 
• 1243580-67-7 C₁₈H₁₆N₂O₂ 

Relevant academic research and scientific papers

Synthesis of thiazolyl-based hydroxamic acids as histone deacetylase inhibitors

Herein we report the synthesis of 4-phenyl substituted thiazolyl-based hydroxamates as histone deacetylase inhibitors. The synthesis of the target compounds is comprised of a Hantzsch-thiazole reaction, a HATU-mediated acylation and a hydroxamic acid synthesis. Preliminary docking results indicated an isozyme selectivity by addressing the lower pocket of HDAC4 with 4-phenyl thiazoles. Surprisingly, this new series of thiazolyl based hydroxamates revealed a moderate HDAC6 inhibitory activity in the low micromolar range. Two of the hydroxamic acids did not show an HDAC4 inhibition up to 100 μM, whilst a third with a 4-pyridinyl CAP moiety displayed a moderate HDAC4 inhibitory activity in the micromolar range.

One-pot synthesis of α-bromo- and α-azidoketones from olefins by catalytic oxidation with in situ-generated modified IBX as the key reaction

Simple one-pot protocols for the syntheses of α-bromoketones and α-azidoketones starting from olefins have been developed by employing catalytic oxidation of the intermediary bromohydrins with in situ-generated modified IBX as the key reaction. The improved procedure involves initial formation of bromohydrin by the reaction of olefin with NBS in acetonitrile-water mixture (1:1) at rt followed by oxidation with in situ-generated 3,4,5,6-tetramethyl-2-iodoxybenzoic acid (TetMe-IBX), produced in catalytic amounts from 3,4,5,6-tetramethyl-2-iodobenzoic and Oxone. α-Bromoketones are further converted in the same pot to the corresponding α-azidoketones using NaN3/NaHCO3. The one-pot conversions are versatile for a variety of olefins that include cyclic as well as acyclic aliphatic olefins and electron-rich and electron-deficient styrenes. Chemoselective bromohydroxylation of electron-rich double bond and subsequent oxidation to the α-bromoketone is demonstrated for a substrate that contains both electron-rich and deficient double bonds.