59866-71-6

Usage

InChI:InChI=1/C22H44N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-18-21(25)24-20(22(26)27)17-15-16-19-23/h20H,2-19,23H2,1H3,(H,24,25)(H,26,27)/t20-/m0/s1

Upstream product

• 76315-00-9 N_α-palmitoyl-N_ε-benzyloxycarbonyl-L-lysine 
• 16079-52-0 sodium salt of L-lysine 
• 112-67-4 n-hexadecanoyl chloride 
• 1155-64-2 N₆-[(benzyloxy)carbonyl]-L-lysine 
• 14464-31-4 palmitic acid N-succinimide ester 
• 57-10-3 1-hexadecylcarboxylic acid 
• 2418-95-3 (S)-2-amino-6-(tert-butoxycarbonylamino)hexanoic acid 

Relevant academic research and scientific papers

COMPOUNDS AND METHODS FOR THE TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY

Disclosed herein are compounds including a single-stranded oligonucleotide (A) having a nucleobase sequence complementary to a portion of the dystrophin pre-mRNA, their preparation, and uses thereof for the treatment of Duchenne muscular dystrophy.

COMPOUND COMPRISING A NUCLEIC ACID AND A HALF-LIFE EXTENSION MOTIF

Disclosed herein are compounds including a nucleic acid (A), their preparation, and their use.

Novel compound N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine

The invention relates to a novel compound N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine (abbreviated hereinafter as compound 1). The compound 1 has a structural formula shown in the description, wherein n equals 1-18, (CH2)n is linear chain preferably, and Fmoc is fluorenylmethoxycarbonyl. As a novel L-lysine derivative compound, the N-2-alkylacryl-N-6-fluorenylmethoxycarbonyl-L-lysine is applicable to the field of medicine.

Purification method of N-2-palmitoyl-N-6-fluorenylmethoxycarbonyl-L-lysine

The invention relates to a purification method of an N-2-palmitoyl-N-6-fluorenylmethoxycarbonyl-L-lysine (hereinafter referred to as a compound 1). According to the purification method, raw materialswith the content of the compound 1 being less than 98.5 percent are treated through three purification manners including a salt formation extraction method, a recrystallization method and a dissolvingand filtering method or any combination of the three purification manners to finally obtain the compound 1 with the content being equal to or greater than 98.5 percent.

LIPID-MODIFIED NUCLEIC ACID COMPOUNDS AND METHODS

Disclosed herein, inter alia, are lipid-modified nucleic acid compounds of the following structure, their preparation, and their use: (I).

Fluorescence polarization method for monitoring fetal lung maturity

The present invention is directed to a fluorescence polarization method for monitoring fetal lung maturity, to various components needed for preparing and carrying out such monitoring, and to methods of making these components.

Melting Behaviour of Some Pure N-Acyl Amino Acids and Peptides

Fifty three tlc pure N-acyl amino acids were synthesized by Schotten-Baumann reaction from glc pure odd and even chain fatty acids and chromatographycally homogeneous amino acids and a few N-acyl peptides were prepared through the carboxylic carbonic anhydride intermediates.The melting points are reported and discussed.