59866-98-7

Usage

Uses

Used in Dye and Pigment Production:
5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID METHYL ESTER is used as a colorant in dye and pigment production due to its yellow hue, which is imparted by the nitro group present in its structure.
Used in Pharmaceutical Manufacturing:
In the pharmaceutical industry, 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID METHYL ESTER is used as an intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and medicinal compounds.
Used in Agrochemical Production:
5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID METHYL ESTER also finds application in the agrochemical sector, where it is utilized as an intermediate in the production of agrochemicals, aiding in the development of pesticides and other agricultural chemicals.
Used in Fine Chemicals Synthesis:
5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID METHYL ESTER is employed as a building block in the synthesis of fine chemicals, which are high-purity chemicals used in various specialized applications.
Used in Research Laboratories:
In research settings, 5-NITRO-NAPHTHALENE-1-CARBOXYLIC ACID METHYL ESTER is used for conducting various chemical reactions and processes, facilitating scientific discovery and innovation.

Upstream product

• 186581-53-3 diazomethane 
• 1975-44-6 5-nitro-1-naphthoic acid 
• 86-55-5 1-naphthalenecarboxylic acid 
• 67-56-1 methanol 
• 6642-29-1 4-nitronaphthalic-1,8-anhydride 
• 2459-24-7 methyl 1-naphthoate 
• 74-88-4 methyl iodide 

Downstream Products

• 91569-19-6 methyl 5-amino-1-naphthoate 

Relevant academic research and scientific papers

The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis

The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.

THERAPEUTIC COMPOUNDS: PYRIDINE AS SCAFFOLD

Compounds of formulas I, IA, and IB or IC or pharmaceutically acceptable salts thereof: wherein A, A1, A2, A3, A4, R2, R3, R4 and n are as defined in the specifications well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Nonacid nitration of benzenedicarboxylic and naphthalenecarboxylic acid esters

When treated with nitrogen dioxide in the presence of ozone and a catalytic amount of iron(III) chloride in inert organic solvent at -10 to +5 °C, benzenedicarboxylic acid diesters 1, 4, and 6 underwent smooth nitration to give the corresponding mononitro derivatives 2/3, 5, and 7, respectively, in good yield (kyodai nitration). Naphthalenecarboxylic acid esters 8 and 11 and naphthalene-1,8-dicarboxylic acid diester 16 were similarly nitrated in the absence of catalyst to give the expected nitro compounds 9/10, 12-15, and 17-22, respectively. Different from conventional nitration based on the combined use of concentrated nitric and sulfuric acids, no hydrolytic cleavage of the ester function was observed under these conditions. The isomer distribution has been determined for the nitration of naphthalenecarboxylic acid esters 8, 11, and 16, and spectral data were collected for less common nitro derivatives. A unique changeover of the orientation mode observed in the kyodai nitration of diester 16, from the initial exclusive meta to the final meta/para, has been discussed in terms of the competition between the electrophilic substitution process involving the nitronium ion (NO2+) and the addition-elimination sequence involving the nitrogen trioxide radical (NO3).