59875-04-6

Basic information

• Product Name: 2-Butyrylaminopropinicacid
• Synonyms: 2-Butyrylaminopropinicacid;Alanin, N-(1-oxobutyl)-;2-Butyramidopropanoic acid;DL-Alanine, N-(1-oxobutyl)-;2-((Butanoyl)amino)propanoic acid;N-(1-Oxobutyl)alanine;N-(1-Oxobutyl)-DL-alanine;Alanine,N-(1-oxobutyl)-
• CAS NO: 59875-04-6
• Molecular Formula: C₇H₁₃NO₃
• Molecular Weight: 159.18
• EINECS: 1592732-453-0
• Mol File: 59875-04-6.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 371.8 °C at 760 mmHg
• Flash Point: 178.7 °C
• Appearance: /
• Density: 1.097
• Vapor Pressure: 1.5E-06mmHg at 25°C
• Refractive Index: 1.458
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• Solubility: DMSO, Methanol
• PKA: 3.69±0.10(Predicted)
• CAS DataBase Reference: 2-Butyrylaminopropinicacid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Butyrylaminopropinicacid(59875-04-6)
• EPA Substance Registry System: 2-Butyrylaminopropinicacid(59875-04-6)

Safety Data

• Hazardous Substances Data: 59875-04-6(Hazardous Substances Data)

Usage

Uses

N-(1-Oxobutyl)-DL-alanine is a reactant used to prepare Vardenafil (V098001, 2HCl salt) which is a selective phosphodiesterase type 5 (PDE5) inhibitor.

InChI:InChI=1/C7H13NO3/c1-3-4-6(9)8-5(2)7(10)11/h5H,3-4H2,1-2H3,(H,8,9)(H,10,11)

Upstream product

• 56-41-7 L-alanin 
• 141-75-3 butyryl chloride 
• 302-72-7 rac-Ala-OH 

Downstream Products

• 224789-21-3 2-(2-ethoxyphenyl)-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 224789-26-8 4-ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydroimidazo[5,1-f][1,2,4]triazin-2-yl)benzenesulfonic acid chloride 
• 1134191-30-2 C₂₅H₃₄N₆O₆S 
• 1134191-27-7 2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetic acid 
• 1134191-22-2 4-(5-thioxo-5H-1,2-dithiol-3-yl)phenyl 2-(4-(4-ethoxy-3-(5-methyl-4-oxo-7-propyl-1,4-dihydroimidazo[1,5-f][1,2,4]triazin-2-yl)phenylsulfonyl)piperazin-1-yl)acetate 
• 224785-90-4 vardenafil 
• 224789-21-3 2-(2-ethoxy-phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 927690-90-2 N-{1-[3-(2-ethoxyphenyl)-5-oxo-4,5-dihydro-[1,2,4]triazin-6-yl]ethyl}butyroamide 

Relevant articles and documents

NOVEL COMPOUNDS FOR USE IN COGNITION IMPROVEMENT

Novel compounds for use in cognition improvement It relates to certain compounds having a polycyclic structure and a -(C=O)NRaRb moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases.

N-BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure.

N-{1-Y3-(2-ETHOXY-5-(4-ETHYLPIPERAZINYL)BENZENESULFONYL)-4,5-DIHYDRO-5-OXO-1,2,4-TRIAZIN-6-YL¨ETHYL}BUTYRAMIDE, THE PREPARATION METHOD AND USE THEREOF

Disclosed are N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)sulfonylphenyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide (which is represented by formula III), its preparation method, intermediates during preparation procedure, preparation method for such intermediates and a method for preparing vardenafil from the compound. In the method for preparing vardenafil, a chloro-sulfonation reaction carries out in the early stage of the preparation procedure.