59880-64-7Relevant academic research and scientific papers
Synthesis of Ni(II) complexes with unsymmetric [O,N,O′]-pincer ligands and their use as precatalysts in carbon-carbon bond formations to access diarylmethanes
Someya, Chika I.,Irran, Elisabeth,Enthaler, Stephan
, p. 136 - 144 (2014/07/08)
1-Acetyl-[1a,3,5-CF3,1-C(=O)CH3] and 1-benzoyl-5-hydroxypyrazolines [1b, 3,5-CF3, 1-C(=O)C 6H5] have been synthesized and reacted with Ni(OAc) 2·4H2O in the presence of PPh3 to form square planar nickel complexes, which revealed a O,N,O′-coordination. An additional coordination site on the nickel center is occupied by one triphenylphosphane ligand. After having investigated the properties of the complexes, catalytic experiments have been carried out to synthesize diarylmethanes. Applying the complexes in the nickel-catalyzed carbon-carbon cross coupling of aryl halides with benzylzinc bromide excellent yields and selectivities of the corresponding diarylmethane have been obtained. Moreover, various experiments have been performed to shed light on the underlying reaction mechanism.
POLYCYCLIC COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS
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Page/Page column 32, (2011/04/24)
Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
2,6-Disubstituted N-arylsulfonyl piperidines as γ-secretase inhibitors
Pissarnitski, Dmitri A.,Asberom, Theodros,Bara, Thomas A.,Buevich, Alex V.,Clader, John W.,Greenlee, William J.,Guzik, Henry S.,Josien, Hubert B.,Li, Wei,McEwan, Michael,McKittrick, Brian A.,Nechuta, Terry L.,Parker, Eric M.,Sinning, Lisa,Smith, Elizabeth M.,Song, Lixin,Vaccaro, Henry A.,Voigt, Johannes H.,Zhang, Lili,Zhang, Qi,Zhao, Zhiqiang
, p. 57 - 62 (2007/10/03)
A novel piperidine series of γ-secretase inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. SAR investigation revealed the requirement for cis-stereochemistry of the substituents attached to the core, which resulted in
SELECTIVE MONO-ALKYLATION AND ARYLATION OF AROMATIC DIHALIDES BY PALLADIUM-CATALYZED CROSS-COUPLING WITH THE GRIGNARD AND ORGANOZINC REAGENTS
Minato, Akio,Tamao, Kohei,Hayashi, Tamio,Suzuki, Keizo,Kumada, Makoto
, p. 845 - 848 (2007/10/02)
Dibromobenzene, dibromothiophenes, dichloro- and dibromopyridine are highly selectively mono-alkylated and arylated with Grignard or organozinc reagents in the presence of palladium complexes as catalysts.
α-(Hydroxy and alkoxy substituted)phenyl-α-(2-piperidinyl)-methanols
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, (2008/06/13)
α-(Hydroxy and alkoxy substituted)phenyl-α-(2-piperidinyl)methanols of the formula SPC1 Where R is hydrogen or lower alkyl, R1 is hydrogen, hydroxy or lower alkoxy, and R2 is phenyl, phenyl-lower alkyl, diphenyl-lower alkyl, phenoxy-lower alkyl or diphenoxy-lower alkyl, and the non-toxic pharmaceutically acceptable acid-addition and quaternary ammonium salts thereof.
