59891-46-2Relevant academic research and scientific papers
The chemistry of small ring compounds. Part 43. Synthesis of 1-substituted cyclopropyl sulfides
Jorritsma, R.,Steinberg, H.,Boer, Th. J. de
, p. 184 - 194 (2007/10/02)
1-Hydroxy- and 1-halocyclopropyl sulfides can be conveniently prepared starting from cyclopropanone.Cyclopropyl sulfides with halogen or a dimethylsulfonium group in the α-position can be transformed into 1-substituted cyclopropyl sulfides with a variety of nucleophiles.This means that the usual difficulties encountered with nucleophilic substitution at three-membered rings - i.e. low rates and ring opening - are largely removed by the presence of an alkylthio group at the same ring carbon atom as the leaving group.
