599151-35-6 Usage
Uses
Used in Pharmaceutical Industry:
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one is used as an anticancer agent for the treatment of hepatocellular carcinoma (HCC) due to its ability to induce apoptosis and inhibit tumor growth in aggressive HCC cell lines and mouse xenograft models.
Used in Drug Development:
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one is used as a research compound for studying the role of transcription factor LSF in cancer and its potential as a therapeutic target. Its ability to induce mitotic arrest and block LSF-stimulated activation of DNA methyltransferase 1 makes it a valuable tool for understanding the molecular mechanisms underlying its anticancer effects.
Used in Drug Delivery Systems:
8-(2-Ethoxyphenyl)-7,8-dihydro-1,3-Dioxolo[4,5-g]quinolin-6(5H)-one is used in the development of drug delivery systems to improve its bioavailability and therapeutic outcomes. Its cell-permeable property allows for the exploration of various drug delivery approaches, such as nanoparticles or liposomes, to enhance its delivery to cancer cells and minimize side effects.
References
1) Grant?et al.?(2012),?Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma; Proc. Natl. Acad. Sci. USA,?109?4503
2) Santhekadur?et al. (2012),?The transcription factor LSF: a novel oncogene for hepatocellular carcinoma; Am. J. Cancer Res.,?2?269
3) Raiasekaran?et al. (2015),?Small molecule inhibitors of Late SV40 Factor (LSF) abrogate hepatocellular carcinoma (HCC): Evaluation using an endogenous HCC model;?Oncotarget?6?26266
4) Chin?et al.?(2016),?Transcription factor LSF-DNMT1 complex dissociation by FQI1 leads to aberrant DNA methylation and gene expression; Oncotarget,?7?83627
Check Digit Verification of cas no
The CAS Registry Mumber 599151-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,9,9,1,5 and 1 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 599151-35:
(8*5)+(7*9)+(6*9)+(5*1)+(4*5)+(3*1)+(2*3)+(1*5)=196
196 % 10 = 6
So 599151-35-6 is a valid CAS Registry Number.
599151-35-6Relevant academic research and scientific papers
QUINOLIN-2(1H)-ONE INHIBITORS OF LATE SV40 FACTOR
-
, (2022/03/14)
The present invention is directed to compositions, methods and kits for treatment of cancer, e.g., hepatocellular carcinoma (HCC). In some embodiments, the present invention discloses the use of a small-molecule compounds of Formula (I) to inhibit tubulin acetylation, to inhibit cell migration, or to modulate cell compaction.
Inhibitors of late SV40 factor (LSF) as cancer chemotherapeutics
-
, (2017/04/11)
The present invention is directed to methods, compositions and kits for treatment of cancer, e.g. heptacellular carcinoma. In some embodiments, the present invention discloses the use of a small-molecule compound of formulas (I)-(XXVI) as disclosed herein to inhibit transcription factor Late SV40 Factor (LSF) for treatment of cancer, e.g., HCC.
[1,3]DIOXOLO[4,5-G]QUINOLINE-6(5H)THIONE AND [1,3]DIOXOLO[4,5-G][1,2,4]TRIAZOLO[1,5-A]QUINOLINE DERIVATIVES AS INHIBITORS OF THE LATE SV40 FACTOR (LSF) FOR USE IN TREATING CANCER
-
, (2013/04/24)
The present invention relates generally to [l,3]dioxolo[4,5-g]quinoline-6(5H)thione and [1,3]dioxolo[4,5-g][1,2,4]triazolo[1,5-a]quinoline derivatives and/or compositions for use in inhibiting, preventing and/or treating cancer, e.g. hepatocellular carcionoma (HCC). In some embodiments, the invention relates to the use of small-molecule compounds to inhibit, prevent and/or treat expression of the transcription factor Late SV40 Factor (LSF) for treatment of HCC or other cancer types.
