8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

Base Information

Chemical Name:8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
CAS No.:599151-35-6
Molecular Formula:C18H17NO4
Molecular Weight:311.337
Hs Code.:
European Community (EC) Number:804-073-7
Nikkaji Number:J3.040.654K
ChEMBL ID:CHEMBL1309542
Mol file:599151-35-6.mol

Synonyms:8-(2-ethoxyphenyl)-7,8-dihydro-(1,3)dioxolo(4,5-g)quinolin-6(5H)-one;factor quinolone inhibitor 1;FQI1 compound

Suppliers and Price of 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Sigma-Aldrich
FQI1 ≥98% (HPLC)
25mg
$ 423.00

Sigma-Aldrich
FQI1 ≥98% (HPLC)
5mg
$ 106.00

Cayman Chemical
FQI 1
10mg
$ 171.00

Cayman Chemical
FQI 1
5mg
$ 96.00

Cayman Chemical
FQI 1
25mg
$ 381.00

Axon Medchem
FQI1 99%
50 mg
$ 368.50

AK Scientific
8-(2-Ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one
25mg
$ 575.00

Total 8 raw suppliers

Chemical Property of 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

Chemical Property:

PSA：60.28000
LogP:3.37320
Storage Temp.:2-8°C
Solubility.:DMSO: soluble10mg/mL (clear solution)
XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:311.11575802
Heavy Atom Count:23
Complexity:443

Purity/Quality:

97% ^*data from raw suppliers

FQI1 ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T,N
Statements: 25-50
Safety Statements: 45-61

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC1=CC=CC=C1C2CC(=O)NC3=CC4=C(C=C23)OCO4
Description FQI1 (599151-35-6) is an inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 μM). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2?In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3?Blocks LSF-stimulated activation of DNA methyltransferase 1.4?Cell permeable.

Technology Process of 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one

There total 6 articles about 8-(2-ethoxyphenyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinolin-6(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₁₉NO₄

: 599151-35-6
8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6-(5H)-one

Guidance literature:: With trifluoroacetic acid; at 70 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 14268-66-7
benzo[1,3]dioxolo-5-ylamine

: 599151-35-6
8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6-(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h / 70 °C / Microwave irradiation

With HATU; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 69038-81-9
2-ethoxy cinnamic acid

: 599151-35-6
8-(2-ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6-(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: HATU / N,N-dimethyl-formamide / 1 h / 20 °C

1.2: 3 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h / 70 °C / Microwave irradiation

With HATU; trifluoroacetic acid; In N,N-dimethyl-formamide;