59916-75-5Relevant academic research and scientific papers
3-Isopropylidenemalic acid: A mechanism-based inhibitor of 3-isopropylmalate dehydrogenase
Chiba, Akira,Arai, Noriko,Eguchi, Tadashi,Kakinuma, Katsumi
, p. 1313 - 1314 (1999)
3-Isopropylidenemalic acid (1) was designed and synthesized as an inhibitor of 3-isopropylmalate dehydrogenase (IPMDH). While being weakly active as substrate, 1 appeared to be a mechanism-based inhibitor (K1 = 60.2 μM) for IPMDH as deduced from the time-dependent and kinetic analyses.
