59940-07-7

Usage

Physical Appearance

White crystalline solid

Common Uses

Reagent in the synthesis of pharmaceuticals and agrochemicals

Versatility

Building block in organic chemistry

Utilization

Production of heterocyclic compounds, dyes, and fluorescent labeling reagents

Application

Coupling agent in peptide synthesis and precursor in preparation of biologically active molecules

Industrial Uses

Production of polymers, plastics, and catalysts

Precaution

Handle with care due to reactivity and potential hazardous properties

Upstream product

• 51-17-2 benzoimidazole 
• 134469-07-1 Benzimidazol-2-thiol 
• 1155-37-9 bis-benzimidazole disulfide 

Downstream Products

• 242459-43-4 benzyl 4-(3-[(2S)-1-(1H-benzo[d]imidazol-2-ylsulfonyl)-2-piperidyl]-1,2,4-oxadiazol-5-ylmethoxy)-1-piperidinecarboxylate 

Relevant academic research and scientific papers

Trichloroisocyanuric acid (TCCA) and N-chlorosuccinimide (NCS) as efficient reagents for the direct oxidative conversion of thiols and disulfides to sulfonyl chlorides

Trichloroisocyanuric acid (TCCA) and N-chlorosuccinimide (NCS) were found to be mild and efficient reagents for the direct oxidative conversion of sulfur compounds to the corresponding arenesulfonyl chlorides in good-to-excellent yields through the oxidative chlorination. The overall process is simple and practical, and it provides convenient access to a variety of aryl or heteroarylsulfonyl chlorides. The mild reaction conditions and the broad substrate scope render this method attractive and complementary to existing syntheses of aryl or heteroarylsulfonyl chlorides. Copyright

Poly(N,N'-Dichloro-N-ethyl-benzene-1,3-disulfonamide) and N,N,N',N'-Tetrachlorobenzene-1,3-disulfonamide as efficient reagents to direct oxidative conversion of thiols and disulfide to sulfonyl chlorides

Poly(N,N'-Dichloro-N-ethyl-benzene-1,3-disulfonamide) (PCBS) and N,N,N',N'-Tetrachlorobenzene-1,3- disulfonamide (TCBDA) were found to be a mild and efficient reagent for the direct oxidative conversion of sulfur compounds to the corresponding arenesulfonyl chlorides in good to excellent yields through the oxidative chlorination. The overall process is simple, practical, and it provides convenient access to a variety of aryl or heteroarylsulfonyl chlorides. The mild reaction conditions and the broad substrate scope render this method attractive, and complementary to existing syntheses of aryl or heteroarylsulfonyl chlorides.

A novel, practical synthesis of sulfonyl chlorides from thiol and disulfide derivatives

Hydrogen peroxide, in the presence of zirconium tetrachloride, is a very efficient reagent for the direct oxidative conversion of thiol and disulfide derivatives into the corresponding sulfonyl chlorides with high purity through oxidative chlorination. Excellent yields, very short reaction times, mild reaction conditions, and the avoidance of harsh reagents are the main advantages of this method.

Heterocyclic compounds as inhibitors of rotomase enzymes

Compounds of the formula: wherein R1, Y, W, A and R2are as defined above are inhibitors of rotamase enzymes in particular FKBP-12 and FKBP-52. The compounds therefore moderate neuronal regeneration and outgrowth and can be used for treating neurological disorders arising from neurodegenerative diseases and nerve damage.

Thiosulfonate Derivatives of Benzimidazole

S-Esters of thiosulfonic acids containing benzimidazol-2-yl, 1-acetylbenzimidazol-2-yl and 2-methoxycarbamoylbenzimidazol-6-yl substituents from the side of the oxidized and sulfide sulfur were synthesized. Various methods of preparation of S-esters of th