5995-27-7Relevant academic research and scientific papers
Synthesis, electrochemical and classical evaluation of the antioxidant activity of three α-aminophosphonic acids: Experimental and theoretical investigation
Mehri, Mouna,Chafai, Nadjib,Ouksel, Louiza,Benbouguerra, Khalissa,Hellal, Abdelkader,Chafaa, Salah
, p. 179 - 189 (2018)
Three α-aminophosphonic acids; namely N-Ethyliminodimethylenediphosphonic acid (N-EDMPA), N-Propyliminodimethylenediphosphonic acid (N-PDMPA) and Ethylenediamine-tetrakis(methylenephosphonic acid) (EDTMP), were synthesized by the reaction of various primary amines, paraformaldehyde and phosphorous acid in acidic medium via Moedritzer-Irani reaction. The structures of the cited compounds were confirmed by UV–Vis, FT-IR, 1H NMR, 13C NMR and 31P NMR spectra. The investigated compounds were screened for their antioxidant activity by mean of the free radical scavenging activity using 1,1-Diphenyl-2-Picryl Hydrazyl (DPPH) and Cyclic Voltammetry (CV) methods. The obtained values of the 50% inhibitory concentration (IC50), show that N-PDMPA exhibit greater antioxidant activity and the order of the antioxidant activities of the studied compounds is: EDTMP N-EDMPA N-PDMPA. Furthermore, this biological activity is in good correlation with the density functional theory (DFT) calculations.
Two new supramolecular metal diphosphonates: Synthesis, characterization, crystal structure and inhibiting effects on metallic corrosion
Gholivand, Khodayar,Yaghoubi, Rouhollah,Farrokhi, Alireza,Khoddami, Shahram
, p. 23 - 30 (2016)
Two new divalent metal(II) aminodiphosphonates with layered structure, namely, Cu(H3L1)2·2H2O (1), [H4L1=methyl-N(CH2PO3H2)2] and Cd2(H2L2)4(2), [H4L2=n-propyl-N(CH2PO3H2)2] were synthesized and characterized. The Cu(II) ions in complex 1 are octahedrally coordinated by four oxygen atoms from two chelating ligands and two phosphonate oxygen atoms from two neighboring Cu(H3L1)2 units. The Cu(H3L1)2 units are interconnected by bridging phosphonate groups, forming a 2-D metal phosphonate layer. The structure of complex 2 contains two unique Cd(II) ions octahedrally-coordinated by six phosphonate oxygen atoms from four H2L2 diphosphonate anions. Corrosion inhibition performances of 1 and 2 were also compared with each other in order to study the effect of combinations of externally added Cd/H4L2 and Cu/H4L1 (1:1 ratio) on corrosion rates of carbon steel. It was found that at pH 3.0, Cd/H4L2 or Cu/H4L1 combinations do not have noticeable corrosion inhibition efficiency for carbon steel. In contrast, at pH 7.0, higher corrosion inhibition efficiency was achieved for Cd/H4L2. Physical characterizations such as scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDS) and Fourier transform infrared spectroscopy (FTIR) were applied to study the corrosion specimens and film material.
Study on the synergistic antibacterial effect of silver-carried layered zirconium alkyl-N,N-dimethylenephosphonate
Liu, Li,Liu, Changhua,Nie, Ling,Jiang, Ting,Hong, Jing,Zhang, Xiaomei,Luo, Liehong,Wang, Xiaolan
, p. 66 - 72 (2015/07/07)
A series of zirconium alkyl-N,N-dimethylenephosphonate silver-carrying (Ag-ZRDP) were successfully prepared and their potential applications as synergistic antibacterial materials were investigated. Silver nanoparticles (Ag NPs), of 30 nm in diameter, were tightly anchored onto the zirconium alkyl-N,N-dimethylenephosphonate (ZRDP), increasing the antibacterial activity of the Ag NPs due to a decrease in the extent of nanoparticle aggregation. Due to the synergistic antibacterial effect of the Ag NPs and ZRDP, the Ag-ZRDP showed a better antibacterial activity than Ag NPs and ZRDP with a minimal inhibition concentration (MIC) of 0.25 and 0.25 μg mL-1 against Escherichia coli and Staphylococcus aureus, respectively. Additionally, the Ag-ZRDP did not show obvious cytotoxicity against mammalian cells (A549 cells), even at a concentration of 256 μg mL-1. Collectively, these properties make the newly synthesized Ag-ZRDP potentially superior as disinfectants and antiseptics for various biomedical and biotechnological applications.
