59965-06-9

Basic information

• Product Name: Vitamin E benzyl ether
• Synonyms: Vitamin E benzyl ether
• CAS NO: 59965-06-9
• Molecular Weight: 520.839
• Mol File: 59965-06-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Vitamin E benzyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Vitamin E benzyl ether(59965-06-9)
• EPA Substance Registry System: Vitamin E benzyl ether(59965-06-9)

Safety Data

• Hazardous Substances Data: 59965-06-9(Hazardous Substances Data)

Upstream product

• 58846-72-3 (2S)-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)acetic acid methyl ester 
• 53730-39-5 (S)-(-)-3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-acetic acid 
• 2385-77-5 (R)-Citronellal 
• 76832-12-7 (6R)-(E)-6,10-dimethyl-3,9-undecadien-2-one 
• 119775-99-4 (S)-1-<3,4-dihydro-2,5,7,8-tetramethyl-6-benzyloxychroman-2-yl>-3'-phenylsulfonyl-2-propanone 
• 119789-58-1 methyl (2R,6R,3E)-6,10-dimethyl-3,9-undecadien-2-yl carbonate 
• 58846-71-2 (-)-(S)-methyl(6-hydroxy-2,5,7,8-tetramethylchroman-2-yl)acetate 
• 162810-67-5 (2S,4'R,8'R)-2',5',11'-α-tocotrienol benzyl ether 
• 59965-21-8 (S)-6-benzyloxy-2,5,7,8-tetramethylchroman-2-ethanol p-toluenesulfonate 
• 53713-30-7 6-benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman-2-ol 
• 114341-71-8 (4R,8R)-1-Bromo-4,8,12-trimethyltridecane 
• 114341-58-1 rac-2-Chloro-3,4-dihydro-2,5,7,8-tetramethyl-6-(phenylmethoxy)-2H-1-benzopyran 
• 1228359-93-0 C₃₇H₅₆O₄ 
• 119775-85-8 (3E,2R,6R)-6,10-dimethyl-2-hydroxy-3,9-undecadiene 

Downstream Products

• 59-02-9 Tocopherol 
• 58-95-7 RRR-α-tocopheryl acetate 

Relevant articles and documents

Highly-chemoselective step-down reduction of carboxylic acids to aromatic hydrocarbons: Via palladium catalysis

Aryl carboxylic acids are among the most abundant substrates in chemical synthesis and represent a perfect example of a traceless directing group that is central to many processes in the preparation of pharmaceuticals, natural products and polymers. Herein, we describe a highly selective method for the direct step-down reduction of carboxylic acids to arenes, proceeding via well-defined Pd(0)/(ii) catalytic cycle. The method shows a remarkably broad substrate scope, enabling to direct the classical acyl reduction towards selective decarbonylation by a redox-neutral mechanism. The utility of this reaction is highlighted in the direct defunctionalization of pharmaceuticals and natural products, and further emphasized in a range of traceless processes using removable carboxylic acids under mild, redox-neutral conditions orthogonal to protodecarboxylation. Extensive DFT computations were conducted to demonstrate preferred selectivity for the reversible oxidative addition and indicated that a versatile hydrogen atom transfer (HAT) pathway is operable.

Synthesis of (2RS,4'R,8'R)-α-tocopherol and related compounds via a 2-chlorochroman

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Total synthesis of all eight stereoisomers of α-tocopheryl acetate. Determination of their diastereoisomeric and enantiomeric purity by gas chromatography

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