174223-29-1 Usage
Uses
Used in Pharmaceutical Industry:
2-METHYL-1,3-THIAZOLE-4-CARBOTHIOAMIDE is used as an antithyroid medication for the treatment of hyperthyroidism, a condition characterized by excessive thyroid hormone production. It is effective in reducing the levels of thyroid hormones, such as thyroxine (T4) and triiodothyronine (T3), thereby alleviating the symptoms and complications associated with hyperthyroidism.
2-METHYL-1,3-THIAZOLE-4-CARBOTHIOAMIDE is used as a pre-treatment agent for patients undergoing thyroid surgery or radioactive iodine treatment. By reducing the levels of thyroid hormones, it helps to minimize the risks and complications associated with these procedures.
In addition to its primary use in treating hyperthyroidism, 2-METHYL-1,3-THIAZOLE-4-CARBOTHIOAMIDE may also have potential applications in other areas of medicine, such as research into thyroid hormone regulation and the development of new therapeutic agents for related conditions. However, it is essential to consider the potential side effects, such as nausea, vomiting, and allergic reactions, as well as the possibility of interactions with other medications, when using 2-METHYL-1,3-THIAZOLE-4-CARBOTHIOAMIDE for any purpose.
Check Digit Verification of cas no
The CAS Registry Mumber 174223-29-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,2,2 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174223-29:
(8*1)+(7*7)+(6*4)+(5*2)+(4*2)+(3*3)+(2*2)+(1*9)=121
121 % 10 = 1
So 174223-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2S2/c1-3-7-4(2-9-3)5(6)8/h2H,1H3,(H2,6,8)
174223-29-1Relevant academic research and scientific papers
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors
Chen, Fei,Chai, Hui,Su, Ming-Bo,Zhang, Yang-Ming,Li, Jia,Xie, Xin,Nan, Fa-Jun
supporting information, p. 628 - 633 (2014/07/07)
Inspired by the thiazole-thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors were prepared and evaluated. Compound 8f was evaluated in vivo in an experimental autoimmune encephalomyelitis (EAE) model and found to be orally efficacious in ameliorating clinical symptoms of EAE mice.
Total synthesis and complete structural assignment of thiocillin i
Aulakh, Virender S.,Ciufolini, Marco A.
supporting information; experimental part, p. 5900 - 5904 (2011/06/10)
The total synthesis of the thiopeptide antibiotic, thiocillin I, is described. This work unequivocally defines the full structure (constitution and configuration) of the natural product as 1.
An improved synthesis of pyridine-thiazole cores of thiopeptide antibiotics
Aulakh, Virender S.,Ciufolini, Marco A.
supporting information; experimental part, p. 5750 - 5753 (2009/12/06)
(Figure Presented) The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.
