174223-29-1 Usage
General Description
2-Methyl-1,3-thiazole-4-carbothioamide, also known as methimazole, is a medication used to treat hyperthyroidism or overactive thyroid. It works by inhibiting the production of thyroid hormones in the body. This chemical is commonly available in tablet form for oral administration. Methimazole may also be used to prepare patients for thyroid surgery or radioactive iodine treatment. It is important to follow the dosage and administration instructions provided by a healthcare professional when using this medication. Common side effects may include nausea, vomiting, and allergic reactions. Additionally, methimazole may have potential interactions with other medications, so it is important to inform a healthcare provider of all current medications before starting treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 174223-29-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,7,4,2,2 and 3 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 174223-29:
(8*1)+(7*7)+(6*4)+(5*2)+(4*2)+(3*3)+(2*2)+(1*9)=121
121 % 10 = 1
So 174223-29-1 is a valid CAS Registry Number.
InChI:InChI=1/C5H6N2S2/c1-3-7-4(2-9-3)5(6)8/h2H,1H3,(H2,6,8)
174223-29-1Relevant articles and documents
Potent and orally efficacious bisthiazole-based histone deacetylase inhibitors
Chen, Fei,Chai, Hui,Su, Ming-Bo,Zhang, Yang-Ming,Li, Jia,Xie, Xin,Nan, Fa-Jun
supporting information, p. 628 - 633 (2014/07/07)
Inspired by the thiazole-thiazoline cap group in natural product largazole, a series of structurally simplified bisthiazole-based histone deacetylase inhibitors were prepared and evaluated. Compound 8f was evaluated in vivo in an experimental autoimmune encephalomyelitis (EAE) model and found to be orally efficacious in ameliorating clinical symptoms of EAE mice.
An improved synthesis of pyridine-thiazole cores of thiopeptide antibiotics
Aulakh, Virender S.,Ciufolini, Marco A.
supporting information; experimental part, p. 5750 - 5753 (2009/12/06)
(Figure Presented) The oxidation of 2-methylthiazoles to 2-formylthiazoles simplifies the implementation of the Bagley variant of the Bohlmann-Rahtz reaction as a key step in a concise new route to pyridine cores of thiopeptide antibiotics.
