5998-48-1

Basic information

• Product Name: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole
• Synonyms: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole
• CAS NO: 5998-48-1
• Molecular Formula: C₁₇H₁₆ClNO
• Molecular Weight: 285.76804
• Mol File: 5998-48-1.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole(5998-48-1)
• EPA Substance Registry System: 2-(4-tert-butylphenyl)-5-chloro-1,3-benzoxazole(5998-48-1)

Safety Data

• Hazardous Substances Data: 5998-48-1(Hazardous Substances Data)

Upstream product

• 939-97-9 4-tert-Butylbenzaldehyde 
• 89-64-5 p-chloro-o-nitrophenol 
• 17200-29-2 5-chloro-benzoxazole 
• 95-85-2 2-hydroxy-5-chloro-aniline 

Relevant articles and documents

Sulfur/DABCO Promoted Reductive Coupling/Annulation Cascade Reaction between o -Hydroxy/Amino Nitrobenzenes and Benzaldehydes

Sulfur/DABCO was found to be an efficient reagent in promoting- the reductive coupling/annulation of o -nitrophenols or o -nitroanilines with benzaldehydes. This method represents a simple, straightforward, and green approach to the construction of benz-oxazoles and benzimidazoles.

Phosphonium acidic ionic liquid: An efficient and recyclable homogeneous catalyst for the synthesis of 2-Arylbenzoxazoles, 2-Arylbenzimidazoles, and 2-Arylbenzothiazoles

A highly efficient and green strategy for the synthesis of 2-Arylbenzoxazoles, 2-Arylbenzimidazoles, and 2-Arylbenzothiazoles catalyzed by phosphonium acidic ionic liquid has been developed via the condensation of o-Aminophenol, o-phenylenediamines, and o-Aminothiophenol, respectively, with aldehydes. The reaction has a good yield, the broad substrate scope, and mild condition. Triphenyl(butyl-3-sulphonyl)phosphonium toluenesulfonate catalyst was easily obtained from cheap and available starting materials through a one-pot synthesis. Its structure was identified by 1H NMR, 13C NMR, 31P NMR, and FT-IR techniques. Other properties including thermal stability and acidity were determined by TGA and Hammett acidity function method. Interestingly, the catalyst can maintain its constantly outstanding performance till the fourth recovery.

One pot synthesis of 2-phenylbenzoxazoles by potassium cyanide assisted reaction of o-aminophenols and benzaldehydes

The 2-phenylbenzoxazoles were obtained in moderate to good yields by reaction of the substituted o-aminophenols with benzaldehydes in the presence of one equivalent of potassium cyanide as an equimolecular catalyst in N,N-dimethylformamide at room temperature.