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4-Pregnen-7beta-ol-3,20-dione, also known as 7β-hydroxy-4-pregnene-3,20-dione, is a steroidal compound derived from the pregnane family. It is characterized by the presence of a hydroxyl group at the 7β position and a ketone group at both the 3 and 20 positions. This chemical is an important intermediate in the synthesis of various steroidal drugs and hormones, such as corticosteroids and sex hormones. The molecular formula for 4-pregnen-7beta-ol-3,20-dione is C21H30O3, and it has a molecular weight of 330.46 g/mol. The compound is typically obtained through chemical synthesis or extraction from natural sources, such as plant or animal tissues. Due to its structural complexity and biological significance, 4-pregnen-7beta-ol-3,20-dione plays a crucial role in pharmaceutical research and development.

600-81-7

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600-81-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 600-81-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 0 respectively; the second part has 2 digits, 8 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 600-81:
(5*6)+(4*0)+(3*0)+(2*8)+(1*1)=47
47 % 10 = 7
So 600-81-7 is a valid CAS Registry Number.

600-81-7Downstream Products

600-81-7Relevant academic research and scientific papers

Novel metabolites of dehydroepiandrosterone and progesterone obtained in Didymosphearia igniaria KCH 6670 culture

Janeczko, Tomasz,Swizdor, Alina,Dmochowska-Gladysz, Jadwiga,Bialonska, Agata,Ciunik, Zbigniew,Kostrzewa-Suslow, Edyta

experimental part, p. 24 - 31 (2012/10/08)

Dehydroepiandrosterone (DHEA) (10) and its five derivatives: testosterone (1), androstenedione (2), 17α-methyltestosterone (6), progesterone (13) and pregnenolone (14) were subjected to microbial transformation by the filamentous fungus Didymosphaeria igniaria KCH 6670. The predominant metabolism of the incubated 5-ene steroids (10 and 14) occurred through 3β-hydroxy-steroid dehydrogenase/5,4-en isomerase pathways resulting in the generation of a 4-en-3-oxo system on ring-A. The transformations of C 19 steroids (1, 2, and 10) included a hydroxylation at 7α position, ketone-alcohol interconversion at C-17 and reduction of the double bond at C-4 and 3-keto group to the 3β-alcohol with 5α- stereochemistry at A/B ring. D. igniaria also carried out 6(7)-dehydrogenation and 6,7β-epoxidation during transformation of DHEA. Under these conditions transformation of DHEA (10) gave four products: 7α-hydroxyandrost-4-en-3, 17-dione (4), 17β-hydroxyandrost-4,6-dien-3-one (11), 17β- hydroxyandrost-6β-epoxy-4-en-3-one (12) and 3β,17β-dihydroxy- 5α-androstane (5). The compounds 11 and 12 are identified as DHEA metabolites for the first time. The transformation of C21 steroids (13 and 14) led to the mixture of mono- (mainly 11α- and 15β-) and dihydroxy- (7α,15β-; 14α,15β-; 11α,15β-; 11α,14α-) products. 7α,15β-Dihydroxypregnan-4-en-3,20- dione (18) and 14α,15β-dihydroxypregnan-4-en-3,20-dione (19) were found to be new compounds. The main product of transformation of 17α-methyltestosterone (6) was 12β-hydroxy-17α- methyltestosterone (7). The results of these transformations demonstrate the dependence of hydroxylation position on the structure of steroid nucleus.

NEW STEROID INHIBITORS OF PGP FOR USE FOR INHIBITING MULTIDRUG RESISTANCE

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Page/Page column 22, (2011/07/07)

The present invention relates to a compound of formula (I) for its use for reversing or inhibiting multidrug resistance.

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