600-92-0

Basic information

• Product Name: 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE
• Synonyms: 20-BETA-DIHYDROPREDNISONE;1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE;17,20,21-Trihydroxypregna-1,4-diene-3,11-dione;(8S,9S,10R,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-17-hydroxy-10,13-dimethyl-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthrene-3,11-dione
• CAS NO: 600-92-0
• Molecular Formula: C₂₁H₂₈O₅
• Molecular Weight: 360.44
• Product Categories: Steroids
• Mol File: 600-92-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility: DMSO (Slightly), Dioxane (Slightly), Methanol (Slightly, Heated)
• Stability: Hygroscopic
• CAS DataBase Reference: 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE(600-92-0)
• EPA Substance Registry System: 1,4-PREGNADIEN-17,20-BETA, 21-TRIOL-3,11-DIONE(600-92-0)

Safety Data

• Hazardous Substances Data: 600-92-0(Hazardous Substances Data)

Upstream product

• 53-06-5 Cortisone 
• 116-59-6 17α,20β,21-trihydroxy-pregn-4-ene-3,11-dione 
• 53-03-2 Prednison 

Downstream Products

• 15847-24-2 11β,17α,20β,21-tetrahydroxy-1,4-pregnadiene-3-one 

Relevant articles and documents

Biotransformation of cortisone with Rhodococcus rhodnii: Synthesis of new steroids

Cortisone is a steroid widely used as an anti-inflammatory drug able to suppress the immune system, thus reducing inflammation and attendant pain and swelling at the site of an injury. Due to its numerous side effects, especially in prolonged and high-dose therapies, the development of the pharmaceutical industry is currently aimed at finding new compounds with similar activities but with minor or no side effects. Biotransformations are an important methodology towards more sustainable industrial processes, according to the principles of “green chemistry”. In this work, the biotransformation of cortisone with Rhodococcus rhodnii DSM 43960 to give two new steroids, i.e., 1,9β,17,21-tetrahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11,20-dione and 1,9β,17,20β,21- pentahydoxy-4-methyl-19-nor-9β-pregna-1,3,5(10)-trien-11-one, is reported. These new steroids have been fully characterized.