60012-67-1Relevant academic research and scientific papers
Sulfone derivatives as 5-HT7 receptor ligands
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Page/Page column 8, (2010/02/09)
The present invention relates to sulfone derivatives of formula (I): Ar—SO2—CR2R3-L-N(R1)2??I wherein Ar, L, R1, R2 and R3 are as defined herein, and pharmaceutically
A FACILE SYNTHESIS OF SPIROKETALS
Brimble, Margaret A.,Officer, David L.,Williams Geoffrey M.
, p. 3609 - 3612 (2007/10/02)
A convenient synthetic approach to spiroketals based on the addition of α-sulfonylcarbanions to lactones is described.
Elimination and Addition Reactions. Part 44. Eliminative Fission of Cycloalkanols
Bury, Adrian,Earl, Harold A.,Stirling, Charles J. M.
, p. 1281 - 1288 (2007/10/02)
Activation parameters for the fission of cyclopropanols and cyclobutanols with phenyl groups α or phenylthio or phenylsulphonyl groups β to the hydroxy group have been obtained.The results show very large differences in reactivity between cyclopropanols and cyclobutanols; such differences are also found in energy profiles for the opening of cycloalkoxide ions obtained by using MINDO3.The results are entirely compatible with other three-membered/four-membered ring comparisons and the role of strain in these systems is discussed.Attempts to extend the well established enforced catalysis of cycloalkanol ring fission to electrophiles other than Broensted acids have failed.
