600168-40-9

Usage

Uses

Used in Chemical Synthesis:
4-[2-(TriMethylsilyl)ethynyl]pyrene is used as an intermediate in the synthesis of Acepyrene (A130950), a novel constituent discovered that belongs to the pyrene class of the polycyclic aromatic hydrocarbons. Its unique structure makes it a valuable component in the development of new compounds with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-[2-(TriMethylsilyl)ethynyl]pyrene may be used as a building block for the development of new drugs, particularly those targeting cancer cells. Its unique chemical properties could potentially be exploited to create novel therapeutic agents with improved efficacy and reduced side effects.
Used in Material Science:
4-[2-(TriMethylsilyl)ethynyl]pyrene could also find applications in the field of material science, where its unique structure and properties may be utilized in the development of advanced materials with specific characteristics, such as improved conductivity, stability, or optical properties.
Used in Research and Development:
Due to its unique structure and potential applications, 4-[2-(TriMethylsilyl)ethynyl]pyrene is likely to be a subject of interest in research and development. Scientists and researchers may use 4-[2-(TriMethylsilyl)ethynyl]pyrene to explore new avenues in chemical synthesis, drug development, and material science, leading to the discovery of innovative applications and technologies.

Upstream product

• 185506-23-4 4-Ethynylpyrene 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1732-26-9 4-bromopyrene 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1377273-10-3 (1S,2R,3S,4R,5S)-4-(6-(3-chlorobenzylamino)-2-(pyren-4-ylethynyl)-9H-purin-9-yl)-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide 

Relevant academic research and scientific papers

Assembly of organosilver coordination frameworks with polycyclic benzenoid aromatic ethynide ligands

Abstract In a series of nine silver(I) complexes synthesized with ethynyl-functionalized condensed-ring benzenoid aromatics, the terminal ethynide group is invariably inserted into an argentophilic Agn (n = 4-5) basket, leading to the generation of coordination chains or multinuclear metallocycles via silver-aromatic interaction and strong face-to-face aromatic π-π stacking interaction. The coordination preferences of the ethynide ligand with respect to the size of the aromatic nucleus proved to be dominant factors in directing the construction of multi-dimensional organosilver(I) networks, which are consolidated by weak intermolecular interactions in supramolecular assembly.

NHC catalysed trimethylsilylation of terminal alkynes and indoles with Ruppert's reagent under solvent free conditions

An organo-catalytic protocol for the trimethylsilylation of terminal alkynes employing Ruppert's reagent (CF3SiMe3) as a trimethylsilyl source has been developed under solvent and fluoride free conditions. This method was found to be very effective as a variety of terminal alkynes bearing aliphatic or aromatic substituents underwent smooth transformation to their corresponding silylated products in excellent yields within a few minutes using N-heterocyclic carbene as an organo-catalyst. This methodology was also applied to the chemospecific N-silylation of indoles. This journal is

Structure-guided design of A3 adenosine receptor-selective nucleosides: Combination of 2-arylethynyl and bicyclo[3.1.0]hexane substitutions

(N)-Methanocarba adenosine 5′-methyluronamides containing known A3 AR (adenosine receptor)-enhancing modifications, i.e., 2-(arylethynyl)adenine and N6-methyl or N6-(3-substituted- benzyl), were nanomolar full agonists of human (h) A3AR and highly selective (Ki ～0.6 nM, N6-methyl 2-(halophenylethynyl) analogues 13 and 14). Combined 2-arylethynyl-N6-3-chlorobenzyl substitutions preserved A3AR affinity/selectivity in the (N)-methanocarba series (e.g., 3,4-difluoro full agonist MRS5698 31, K i 3 nM, human and mouse A3) better than that for ribosides. Polyaromatic 2-ethynyl N6-3-chlorobenzyl analogues, such as potent linearly extended 2-p-biphenylethynyl MRS5679 34 (Ki hA3 3.1 nM; A1, A2A, inactive) and fluorescent 1-pyrene adduct MRS5704 35 (Ki hA3 68.3 nM), were conformationally rigid; receptor docking identified a large, mainly hydrophobic binding region. The vicinity of receptor-bound C2 groups was probed by homology modeling based on recent X-ray structure of an agonist-bound A2AAR, with a predicted helical rearrangement requiring an agonist-specific outward displacement of TM2 resembling opsin. Thus, the X-ray structure of related A2AAR is useful in guiding the design of new A3AR agonists.