60026-20-2

Usage

Uses

Used in Pharmaceutical Industry:
Ethanone, 1-(2-pyrrolidinyl)(9CI) is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the formation of complex organic molecules. Its high reactivity makes it a valuable component in drug development, contributing to the creation of new and innovative medications.
Used in Research:
In the field of research, Ethanone, 1-(2-pyrrolidinyl)(9CI) serves as a versatile compound for studying chemical reactions and exploring new synthetic pathways. Its distinct properties and reactivity make it an essential tool for researchers working on the development of novel organic compounds and understanding reaction mechanisms.
Used in Organic Synthesis:
Ethanone, 1-(2-pyrrolidinyl)(9CI) is used as a solvent in organic synthesis, enabling the formation of a wide range of organic compounds. Its unique properties allow for efficient reactions and improved yields, making it a preferred choice for chemists in various organic synthesis applications.

Upstream product

• 115186-37-3 tert-butyl (2S)-2-{[N-methoxy(N-methyl)amino]carbonyl}pyrrolidine-1-carboxylate 
• 91550-08-2 (S)-2-acetylpyrrolidine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

Total Synthesis of the Highly N-Methylated Acetylene-Containing Anticancer Peptide Jahanyne

The first total synthesis of the highly N-methylated acetylene-containing lipopeptide jahanyne, an apoptosis-inducing natural product from marine cyanobacteria, is reported. A late-stage solution-phase coupling enabled introduction of the C-terminal keton

Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors

In this paper the synthesis and structure-activity relationships of two classes of electrophile-based DPP IV inhibitors, the ketopyrrolidines and ketoazetidines, is discussed. The in vitro potency, stability and ex vivo experiments were performed on select compounds within these series to determine their inhibitory capacity in plasma. In this paper, the synthesis and structure-activity relationships (SAR) of two classes of electrophile-based dipeptidyl peptidase IV (DPP IV) inhibitors, the ketopyrrolidines and ketoazetidines, is discussed. The SAR of these series demonstrate that the 2-thiazole, 2-benzothiazole, and 2-pyridylketones are optimal S1′ binding groups for potency against DPP IV. In addition, both cyclohexyl glycine (CHG) and octahydroindole carboxylate (OIC) serve as the most potent S2 binding groups within each series. Stereochemistry at the α-position of the central ring is relevant to potency within the ketopyrrolidines series, but not in the ketoazetidine series. Finally, the ketoazetidines display enhanced stability over the corresponding ketopyrrolidines, while maintaining their potency. In fact, certain stabilized ketoazetidines can maintain their in vitro potency and inhibit DPP IV in the plasma for up to 6 h.