60033-23-0

Basic information

• Product Name: Acetic acid, (methyldithio)-
• Synonyms: carboxymethyl methyl disulfide;methyldithio-acetic acid;Acetic acid,(methyldithio);S-thiomethylthioglycolic acid;methylenedithioacetic acid;methyldisulfanyl-acetic acid
• CAS NO: 60033-23-0
• Molecular Formula: C3H6O2S2
• Molecular Weight: 138.20900
• Mol File: 60033-23-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 263.3±23.0 °C(Predicted)
• Density: 1.373±0.06 g/cm3(Predicted)
• CAS DataBase Reference: Acetic acid, (methyldithio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, (methyldithio)-(60033-23-0)
• EPA Substance Registry System: Acetic acid, (methyldithio)-(60033-23-0)

Safety Data

• Hazardous Substances Data: 60033-23-0(Hazardous Substances Data)

Upstream product

• 624-92-0 Dimethyldisulphide 
• 505-73-7 disulfanediyldiacetic acid 
• 2949-92-0 methanethiosulfonic acid S-methyl ester 
• 68-11-1 mercaptoacetic acid 
• 75-18-3 dimethylsulfide 
• 5813-48-9 Methanesulfenyl chloride 

Downstream Products

• 485801-41-0 C₅₉H₉₃NO₁₅S₂Si₂ 

Relevant articles and documents

Synthesis of S-thiomethyl MAG3, radiolabelling with technetium-99m and biological evaluation

Protection of the thiolate function of the mercaptoacetyltriglycine (MAG3) by S-thiomethyl group allows automatic deprotection of the protecting group during technetium-99m radiolabelling by transchelation using stannous chloride dihydrate as r

SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS

This invention provides compounds of formula (1) wherein X is C3-7 cycloalkyl, pyridinyl, pyrimidinyl or phenyl ring optionally substituted as described in claim 1, R1, R3 and R4 are chosen from the groups listed in claim 1. R2 is chosen from various unsaturated acyl groups listed in claim 1, with certain compounds being disclaimed. Use as tyrosine kinase inhibitors for the treatment of cancer and certain kidney diseases such as polycystic kidney disease.

Cleavage of S-S bond by nitric oxide (NO) in the presence of oxygen: A disproportionation reaction of two disulfides

Disulfide bond was cleaved by a catalytic amount of nitric oxide in the presence of oxygen, which was confirmed by experiments employing two symmetrical disulfides. The reaction resulted in the formation of unsymmetrical disulfides in nearly 50% yields. The steric hindrance of alkyl disulfide slowed the reaction rate, and an electron-donating group on the aryl disulfide promoted the reaction. The substituent and S-nitrosothiol effects suggested that the reaction was initialized with an oxidative process by NO+.