60043-55-2Relevant academic research and scientific papers
LACTONISIERUNG VON MAKROLID-SECOSAEUREN MIT "PUSH-PULL ACETYLENEN"
Gais, H.-J.
, p. 273 - 276 (1984)
A highly efficient method for the macrolactonization of seco-acids is described.Seco-acids are converted into stable enolesters 3 by the acetylene 1, which are cyclized under proton or Lewis acid catalysis.This new method has been successfully applied to the lactonization of the 7-epi-brefeldin A seco-acids 8a, b.
