Tetrahedron Letters p. 273 - 276 (1984)
Update date:2022-08-05
Topics: NMR spectroscopy High-performance liquid chromatography (HPLC) Reaction Conditions Lactonization
Gais, H.-J.
A highly efficient method for the macrolactonization of seco-acids is described.Seco-acids are converted into stable enolesters 3 by the acetylene 1, which are cyclized under proton or Lewis acid catalysis.This new method has been successfully applied to the lactonization of the 7-epi-brefeldin A seco-acids 8a, b.
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