60051-46-9Relevant academic research and scientific papers
A study on the catalytic pathways of the hydroalkoxycarbonylation reaction of styrene
Benedek, Csilla,Szalontai, Gabor,Goemoery, Agnes,Toeroes, Szilard,Heil, Balint
, p. 147 - 155 (1999)
The catalytic pathways of the Pd(PPh3)2Cl2/SnCl2-catalysed styrene hydroalkoxycarbonylation reaction have been elucidated. Using deuterium labelling, the different reaction products were detected by mass spectral analysis and the deuterium content and its distribution determined by 1H-, 2H- and 13C-NMR methods. The great number of labelled species supports the assumption that the hydrido (Pd-H) route is the operating mechanism of this system. Alkyl-metal intermediates easily undergo β-hydride elimination. This process is reversible for both isomers even at low reaction temperature
Comparative investigation of the regioselectivity in styrene and α-methylstyrene hydroalkoxycarbonylation as a function of palladium catalyst structure
Benedek, Csilla,Toroes, Szilard,Heil, Balint
, p. 85 - 93 (2007/10/03)
Catalytic pathways of the styrene and α-methyl-styrene hydroalkoxycarbonylation in the presence of Pd(PPh3)2Cl2 and Pd(PPh3)2Cl2/SnCl2 catalyst precursors have been suggested. As a method, deuterium labelling with EtOD has been applied and it resulted in mixtures of mono- and polydeuterated reaction products, detected and determined by NMR methods. Comparative elucidation of the mechanisms governing these systems does support the assumption that the hydrido route is operative. The different behaviour of the metal-alkyl intermediates accounts for the observed strong influence of catalyst and substrate structure on regioselectivity.
