60055-01-8Relevant academic research and scientific papers
Catecholamines in Rigid Framework: Synthesis and Pharmacological Evaluation of cis- and trans-6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols
Kumar, Ashok,Singh, Rajeshwar,Khanna, J. M.,Anand, Nitya,Srimal, R. C.
, p. 880 - 884 (2007/10/02)
6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols (cis-1 and trans-2), incorporating the α-rotameric form of norepinephrine in the trans-extended conformation have been synthesized and evaluated for their biological activity. trans-6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocylohepten-5-ol (2) is found to possess marked β2-stimulant activity.
