67090-89-5Relevant academic research and scientific papers
On the conformation of 8-membered ring heterocycles - Dynamic and static conformational analysis of acylated hexahydrobenzazocines
Hassner, Alfred,Amit, Boaz,Marks, Vered,Gottlieb, Hugo E.
, p. 1256 - 1261 (2007/10/03)
A high-field NMR analysis of several acylated hexahydrobenzazocines indicates that, surprisingly, ring methylene groups are typically diastereotopic at room temperature, as the barriers for the process of enantiomerization of the eight - membered ring are
Catecholamines in Rigid Framework: Synthesis and Pharmacological Evaluation of cis- and trans-6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols
Kumar, Ashok,Singh, Rajeshwar,Khanna, J. M.,Anand, Nitya,Srimal, R. C.
, p. 880 - 884 (2007/10/02)
6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ols (cis-1 and trans-2), incorporating the α-rotameric form of norepinephrine in the trans-extended conformation have been synthesized and evaluated for their biological activity. trans-6-Amino-1,2-dihydroxy-6,7,8,9-tetrahydro-5H-benzocylohepten-5-ol (2) is found to possess marked β2-stimulant activity.
