600723-92-0

Basic information

• Product Name: N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine
• Synonyms: N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine
• CAS NO: 600723-92-0
• Molecular Weight: 715.7
• Mol File: 600723-92-0.mol

Chemical Properties

• CAS DataBase Reference: N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine(CAS DataBase Reference)
• NIST Chemistry Reference: N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine(600723-92-0)
• EPA Substance Registry System: N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine(600723-92-0)

Safety Data

• Hazardous Substances Data: 600723-92-0(Hazardous Substances Data)

Upstream product

• 102690-88-0 bis(2-cyanoethyl) diisopropylamidophosphite 
• 76512-82-8 5'-O-(4,4'-dimethoxytrityl)deoxycytidine 

Downstream Products

• 600723-94-2 N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-P-(2-cyanoethyl)cytidylyl-(3'->5')-3'-O-acetylthymidine 
• 600723-93-1 N⁴-bis(2-cyanoethoxy)phosphoryl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidin-3'-yl 

Relevant articles and documents

Synthesis and properties of oligodeoxynucleotides possessing N-phosphoryl groups

This paper deals with the synthesis and properties of oligodeoxynucleotides of a Dickerson-Drew sequence, d(CGCGAATTCGCG), in which one of the four cytosine bases has been replaced with an N-phosphorylated or N-diethylphosphorylated cytosine base in order to study the effect of the N-phosphoryl or N-diethoxyphosphoryl group on their structural property and hybridization affinity. The CD spectra of these self-complementary duplexes showed the typical B DNA-type shape with very minor changes. In contrast, it was found from Tm experiments that N-phosphoryl groups destabilized the DNA duplexes significantly through steric hindrance and electronic repulsion. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).