76512-82-8Relevant articles and documents
MODIFIED NUCLEOTIDES FOR SYNTHESIS OF NUCLEIC ACIDS, A KIT CONTAINING SUCH NUCLEOTIDES AND THEIR USE FOR THE PRODUCTION OF SYNTHETIC NUCLEIC ACID SEQUENCES OR GENES
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Paragraph 0124, (2020/08/05)
A modified nucleotide, intended for the synthesis of long chain nucleic acids by enzymatic processes, comprising a “natural” nitrogenous base or a natural nitrogenous base analogue, a ribose or deoxyribose carbohydrate, and at least one phosphate group, characterized in that said nucleotide comprises at least one R group, termed the modifier group, carried by said nitrogenous base or analogue and/or by the oxygen in position 3′ of the ribose or deoxyribose molecule, making it possible to block the polymerization of said nucleotide and/or to allow the interaction of said nucleotide with another molecule, such as a protein, during the nucleic acid synthesis, R comprising at least one functional terminal group.
Monomers for oligonucleotide synthesis with linkers carrying reactive residues: I. The synthesis of deoxynucleoside derivatives with methoxyoxalamide groups in heterocyclic bases
Abramova,Vasil'eva,Ivanova,Shishkin,Sil'nikov
, p. 224 - 233 (2007/10/03)
A number of monomers for the standard phosphoamidite oligodeoxynucleotide synthesis that carry reactive methoxyoxalamide groups attached to the thymidine, 2′-deoxycytidine, and 2′-deoxyadenosine heterocyclic bases were prepared.
Commercial-scale synthesis of protected 2′-deoxycytidine and cytidine nucleosides
Divakar, Kikkeri J.,Sawant, Chitra M.,Mulla,Zemse, Deepak V.,Sitabkhan, Sakina M.,Ross, Bruce S.,Sanghvi, Yogesh S.
, p. 1321 - 1325 (2007/10/03)
Transformation of 2′-deoxyuridine and uridine analogs to protected 2′-deoxycytidine and cytidine analogs has been investigated by two different methods. First, traditional triazolation protocol and second p-nitrophenoxylation method. Our studies conclude
