600725-16-4

Upstream product

• 92547-10-9 N¹-(5-chloro-2-nitrophenyl)-N³,N³-dimethylpropane-1,3-diamine 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 700-37-8 4-chloro-2-fluoro-nitrobenzene 

Downstream Products

• 600724-59-2 4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carboxylic acid [1-[6-chloro-1-(3-dimethylaminopropyl)-1H-benzimidazol-2-yl]-2-(3,4-dibromo-phenyl)-ethyl]-amide 

Relevant academic research and scientific papers

Indole RSK inhibitors. Part 2: Optimization of cell potency and kinase selectivity

A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.

Novel substituted piperidines, pharmaceutical compositions containing these compounds, their use and processes for the preparation thereof

The present invention relates to substituted piperidines of general formula wherein R, R2 to R5, A, X, Z and n are defined as in claim 1, the tautomers, diastereomers, enantiomers, mixtures and salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly CGRP-antagonistic properties, pharmaceutical compositions containing these compounds, the use thereof and processes for the preparation thereof.