Bioorganic and Medicinal Chemistry Letters p. 738 - 742 (2012)
Update date:2022-09-26
Topics:
Kirrane, Thomas M.
Boyer, Stephen J.
Burke, Jennifer
Guo, Xin
Snow, Roger J.
Soleymanzadeh, Lida
Swinamer, Alan
Zhang, Yunlong
Madwed, Jeffery B.
Kashem, Mohammed
Kugler, Stanley
O'Neill, Margaret M.
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
View Morelianyungang jinkang pharmaceutical technology co., ltd.
Contact:008651885445517
Address:Jinshan industrial park, Ganyu county, Lianyungang, Jiangsu Province, 222115, China
website:http://www.shochem.com
Contact:021-50800795
Address:No.1043, Halei Rd, Zhangjiang Hi-Tech Park, Shanghai, Postcode 201203, China
Contact:(1) 206-3550089
Address:5115 NE 8TH PL, Renton, WA 98059 USA
Taixing Joxin Bio-tec Co.,Ltd.
website:http://www.joxbio.com
Contact:86-523-87558858 87612088
Address:No.88, chengdong industrial park
Anhui Sunsing Chemicals Co.,Ltd
website:http://www.sunsingchem.com
Contact:0086-566-2023179
Address:Jin An industry park, Chizhou economic technical development zone, Anhui
Doi:10.1055/s-2004-822359
(2004)Doi:10.1021/jo00422a028
(1977)Doi:10.1016/S0040-4039(00)78089-0
(1976)Doi:10.1021/jm00211a031
(1977)Doi:10.1021/jm00320a003
(1966)Doi:10.1021/acschembio.7b00949
(2018)