Bioorganic and Medicinal Chemistry Letters p. 738 - 742 (2012)
Update date:2022-09-26
Topics:
Kirrane, Thomas M.
Boyer, Stephen J.
Burke, Jennifer
Guo, Xin
Snow, Roger J.
Soleymanzadeh, Lida
Swinamer, Alan
Zhang, Yunlong
Madwed, Jeffery B.
Kashem, Mohammed
Kugler, Stanley
O'Neill, Margaret M.
A series of inhibitors for the 90 kDa ribosomal S6 kinase (RSK) based on an 1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]indole-8-carboxamide scaffold were optimized for cellular potency and kinase selectivity. This led to the identification of compound 24, BIX 02565, an attractive candidate for use in vitro and in vivo to explore the role of RSK as a target for the treatment heart failure.
View MoreNanjing Sunsure Chemical Technology Co., Ltd
website:http://www.sunsurechem.com/
Contact:+86-025-58535435
Address:Southeast University Science Park(SEUSP) Gaoxin, Nanjing, Jiangsu 210032, China
website:http://www.easchem.com
Contact:+86-731-89722861 89722891
Address:2/F-4/Bld Colorful Palace, No.605 Changsha Ave, Yuhua Area Changsha Hunan China.
NanJing KaiHeng Chemical CO., LTD.
Contact:+86-25-85768391
Address:RM.1704, D, WANDA PLAZA, NO.110, MIDDLE JIANGDONG ROAD, NANJING, CHINA
Ceresking Ecology & Technology co.,ltd
Contact:86 22 66218397
Address:Room 1613, Zheshang Mansion, No. 1988, Yingbin Avenue, Binhai New District, Tianjin,China.
chengdu firsterchem Pharmaceutical Co., Ltd.
Contact:028-66825849
Address:chengdu
Doi:10.1055/s-2004-822359
(2004)Doi:10.1021/jo00422a028
(1977)Doi:10.1016/S0040-4039(00)78089-0
(1976)Doi:10.1021/jm00211a031
(1977)Doi:10.1021/jm00320a003
(1966)Doi:10.1021/acschembio.7b00949
(2018)