57944-10-2

Usage

Uses

Used in Pharmaceutical Industry:
2,5-Anhydro-D-allonothioamide 3,4,6-Tribenzoate is used as a key intermediate in the synthesis of Tiazofurin (T437200) for its potential therapeutic application in cancer treatment. 2,5-Anhydro-D-allonothioaMide 3,4,6-Tribenzoate contributes to the development of new drugs that can target and combat cancer cells effectively.
Used in Cancer Treatment:
2,5-Anhydro-D-allonothioamide 3,4,6-Tribenzoate is used as a precursor in the production of Tiazofurin (T437200), which is being explored for its potential as an anticancer agent. 2,5-Anhydro-D-allonothioaMide 3,4,6-Tribenzoate plays a significant role in the development of therapeutic strategies aimed at treating various types of cancer by enhancing the effectiveness of cancer treatments and improving patient outcomes.

InChI:InChI=1/C27H23NO7S/c28-24(36)23-22(35-27(31)19-14-8-3-9-15-19)21(34-26(30)18-12-6-2-7-13-18)20(33-23)16-32-25(29)17-10-4-1-5-11-17/h1-15,20-23H,16H2,(H2,28,36)

Upstream product

• 23316-67-8 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 
• 14278-72-9 [phenyl(sulfanyl)phosphoroso]benzene 
• 67-63-0 isopropyl alcohol 
• 98-88-4 benzoyl chloride 
• 58-63-9 Inosine 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 

Downstream Products

• 61367-53-1 2-(5-benzoyloxymethyl-furan-2-yl)-thiazole-5-carboxylic acid methyl ester 
• 60084-12-0 2-(4-carboethoxythiazol-2-yl)-5-((benzoyloxy)methyl)furan 
• 60084-09-5 ethyl 2-(2',3',3''-tri-O-benzoyl-β-D-apiofuranosyl)thiazole-4-carboxylate 
• 61367-49-5 2-(tri-O-benzoyl-α-D-ribofuranosyl)-thiazole-4-carboxylic acid ethyl ester 
• 60084-10-8 tiazofurin 
• 60084-14-2 2-(5'-Hydroxymethylfuran-2'-yl)thiazole-4-carboxamide 
• 60084-11-9 2-(2',3'-O-isopropylidene-β-D-ribofuranosyl)thiazole-4-carboxamide 

Relevant academic research and scientific papers

COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF AS INHIBITORS OF RAN GTPASE

Compounds of general formula IA, IB and IC outlined below, including pharmaceutically acceptable salts, solvates and hydrates thereof. Such compounds and pharmaceutical compositions comprising them may be used in medical conditions involving Ran GTPase.

A modified synthesis of tiazofurin

An improved synthesis of tiazofurin is described from 1-O-acetyl-2,3,5- tri-O-benzoyl-β-D-ribofuranose.

Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases

A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria.

Procedures for obtaining ribo-C-nucleosides

Novel procedures for obtaining ribo-C-nucleosides, including especially 2-β-D-ribofuranosylthiazole-4-carboxylamide (tiazofirin) and 2-β-D-ribofuranosylselenazole-4-carboxylamide (sylenazofurin) and synthesis intermediates thereof. The novel procedures in

Process for the production of 2-β-D-ribofuranosylthiazole-4-carboxamide

An improved multi-step process for the production of 2-β-D-ribofuranosylthiazole-4-carboxamide.

Synthesis and antiviral activity of certain thiazole C nucleosides

A general reaction of glycosyl cyanides with liquid hydrogen sulfide in the presence of 4 dimethylaminopyridine to provide the corresponding glycosylthiocarboxamides is described. These glycosylthiocarboxamides were utilized as the precursors for the synt