60092-92-4Relevant academic research and scientific papers
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists
Yamamoto, Takashi,Fujita, Koichi,Asari, Sayaka,Chiba, Akira,Kataba, Yuka,Ohsumi, Koji,Ohmuta, Naoko,Iida, Yuko,Ijichi, Chiori,Iwayama, Satoshi,Fukuchi, Naoyuki,Shoji, Masataka
, p. 3736 - 3740 (2008/02/07)
A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA1/CHO cells and rHSC cells were evaluated. Among them, 3-(4-{4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- yl}-benzylsulfanyl)-propionic acid (34) showed the most potent activities.
DFT-HSAB prediction of regioselectivity in 1,3-dipolar cycloadditions: Behavior of (4-substituted)benzonitrile oxides towards methyl propiolate
Ponti, Alessandro,Molteni, Giorgio
, p. 1156 - 1161 (2007/10/03)
The regioselectivity of 1.3-di-polar cycloadditions between (4-substituted)benzonitrile oxides and methyl propiolate cannot be rationalized on the basis of the electron demand of the reactants or frontier molecular-orbital theory. To this problem, we have
1,3-Dipolar cycloaddition of nitrile oxides to methyl 3-(p- nitrobenzoyloxy)acrylate: Methyl 3-(p-nitrobenzoyloxy)acrylate as a methyl propiolate equivalent with reverse regioselectivity
Zong, Kyukwan,Shin, Seung Il,Jeon, Dong Ju,Lee, Jung No,Ryu, Eung K.
, p. 75 - 78 (2007/10/03)
3-Aryl-4-methoxycarbonylisoxazoles were prepared from the reaction of a variety of substituted benzonitrile oxides with methyl 3-(p- nitrobenzoyloxy)acrylate in moderate to good yields.
