58402-81-6

Usage

Uses

Used in Organic Synthesis:
(Z)-4-nitrobenzohydroximoyl chloride is used as a reagent for the synthesis of various organic compounds. Its structure, which includes a chloride and a nitro group, provides unique properties that facilitate specific chemical reactions, making it a versatile component in the creation of a range of derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (Z)-4-nitrobenzohydroximoyl chloride is utilized as a reactant in the development of complex organic compounds that may have potential applications in drug discovery and medicinal chemistry. Its unique properties allow for the creation of novel molecules with potential therapeutic benefits.
Used in Chemical Research:
(Z)-4-nitrobenzohydroximoyl chloride is also employed in chemical research, where it can be used to study the effects of nitroaromatic compounds on various chemical reactions and to explore new synthetic pathways for the production of innovative organic molecules.
Safety Precautions:
Despite its utility in various applications, (Z)-4-nitrobenzohydroximoyl chloride should be handled with care due to its potentially hazardous nature. Proper safety measures and precautions should be taken to minimize risks associated with its use in research and industrial settings.

Upstream product

• 1129-37-9 4-nitrobenzaldehyde oxime 
• 555-16-8 4-nitrobenzaldehdye 
• 1129-37-9 4-nitrobenzaldehyde oxime 

Downstream Products

• 25283-96-9 3-(4-methoxyphenyl)-5-methyl-1,2,4-oxadiazole 
• 106478-96-0 7a-morpholin-4-yl-3-(4-nitro-phenyl)-3a,4,5,6,7,7a-hexahydro-benzo[d]isoxazole 
• 105755-41-7 C₉H₆Cl₂N₂O₄ 
• 105755-42-8 C₁₄H₉ClN₂O₄ 
• 93824-59-0 C₉H₇ClN₂O₄ 
• 73921-05-8 4,6-Diamino-3-(4-nitrophenyl)isoxazolo<5,4-b>pyridin-5-carbonitril 
• 89333-93-7 3-(4-nitrophenyl)-5-(4-nitrophenylthio)-1,2,4-oxadiazole 
• 89333-94-8 5-(2,4-dinitrophenylthio)-3-(4-nitrophenyl)-1,2,4-oxadiazole 
• 137250-99-8 5-(4-Methoxy-phenyl)-5-methylsulfanyl-3-(4-nitro-phenyl)-[1,4,2]oxathiazole 
• 89333-92-6 5-(1-naphthylthio)-3-(4-nitrophenyl)-1,2,4-oxadiazole 
• 89333-95-9 5-(2-chloro-4,6-dinitrophenylthio)-3-(4-nitrophenyl)-1,2,4-oxadiazole 
• 2574-03-0 4-nitrobenzonitrile oxide 
• 61713-82-4 3,5-bis(p-nitrophenyl)-1,2,4-oxadiazole 4-oxide 
• 188118-35-6 3-(4-Nitro-phenyl)-5-phenyl-[1,2,4]oxadiazole 4-oxide 

Relevant academic research and scientific papers

INHIBITORS OF YAP/TAZ-TEAD ONCOPROTEINS, SYNTHESIS AND USE THEREOF

Disclosed herein are synthesis and use of covalent inhibitors selective for Transcriptional Enhancer Factor TEF-1 (TEAD1), which can be used for treatment of cancers such as glioblastoma, gastric cancer, colorectal cancer, pancreatic ductal adenocarcinoma (PDAC), and malignant pleural mesothelioma (MPM). Further disclosed herein are pharmaceutical compositions including the TEAD1 inhibitor and methods of treating cancers using the same.

Leaving Group Assisted Strategy for Photoinduced Fluoroalkylations Using N-Hydroxybenzimidoyl Chloride Esters

Redox-active esters (RAEs) as alkyl radical precursors have been extensively developed for C?C bond formations. However, the analogous transformations of fluoroalkyl radicals from the corresponding acid or ester precursors remain challenging because of the high oxidation potential of the fluoroalkyl carboxylate anions. The newly developed N-hydroxybenzimidoylchloride (NHBC) ester provides a general leaving group assisted strategy to generate a portfolio of fluoroalkyl radicals, and can be successfully applied in photoinduced decarboxylative hydrofluoroalkylation and heteroarylation of unactivated olefins. In addition, DFT calculations revealed that the NHBC ester proceeds by the fluorocarbon radical pathway, whereas other well-known RAEs proceed by the nitrogen radical pathway.

Reaction between (Z)-Arylchlorooximes and α-Isocyanoacetamides: A procedure for the synthesis of Aryl-α-ketoamide amides

(Z)-Arylchlorooximes and α-isocyanoacetamides undergo a smooth reaction to produce 1,3-oxazol-2-oxime derivatives in good yields. Opening of the oxazole ring and deoximation reaction give a facile access to aryl-α-ketoamide amides, a class of privileged s

Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides

A number of structural analogues of the known toxicant para- aminopropiophenone (PAPP) have been prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed for alkyl analogues of PAPP (aminophenones 1-20; compound 6 metHb% = 74.1 ± 2). Besides lipophilicity, this structural sub-class suggested there were certain structural requirements for activity, with both branched (10-16) and cyclic (17-20) alkyl analogues exhibiting inferior in vitro metHb induction. Of the four candidates (compounds 4, 6, 13 and 23) evaluated in vivo, 4 exhibited the greatest toxicity. In parallel, aminophenone bioisosteres, including oximes 30-32, sulfoxide 33, sulfone 34 and sulfonamides 35-36, were found to be inferior metHb inducers to lead ketone 4. Closer examination of Hammett substituent constants suggests that a particular combination of the field and resonance parameters may be significant with respect to the redox mechanisms behind PAPPs metHb toxicity.

Synthesis, larvicidal activity, and SAR studies of new benzoylphenylureas containing oxime ether and oxime ester group

A series of new structural benzoylphenylureas (BPUs) containing oxime ether and oxime ester group were designed and synthesized. The larvicidal activities against Oriental armyworm and mosquito of these benzoylphenylureas were evaluated and the result of bioassay displayed specific structure-activity relationship (SAR). Most of the compounds exhibited excellent larvicidal activities against Oriental armyworm and mosquito. Interestingly, some compounds showed different structure-activity relationship towards diamondback moth, beet armyworm, and corn borer although three tested insects all belong to the same insect order.

Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases

A series of isothiazolopyrimidines and isoxazolopyrimidines were synthesized and identified as potent KDR inhibitors. SAR studies led to isothiazolopyrimidine urea analogs that potently inhibit VEGFR tyrosine kinases (KDR enzymatic and cellular IC50

Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates

Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react with azides and nitrile oxides, providing ready access to 1,4-disubstituted 1,2,3-triazoles and 3,4-disubstituted isoxazoles, respectively. The process is highly reliable and exhibits an unusually wide scope with respect to both components. Computational studies revealed a stepwise mechanism involving unprecedented metallacycle intermediates, which appear to be common for a variety of dipoles.

A Clear Demonstration of the Stereoelectronic Effect of Nitrogen in Chloride Ion loss by (E)- and (Z)-Hydroximoyl Chlorides

(E)-Benzohydroximoyl chlorides have been examined for the first time and are shown to react (as the conjugate ion) > 10E7-fold more slowly than the corresponding (Z)-benzohydroximoyl chloride anions.This large rate difference is attributed to the favourab