60093-74-5

Usage

Uses

Used in Pharmaceutical Research:
(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL is used as a building block for the development of new drugs due to its unique structural features and reactivity. Its chiral nature and the presence of the propylamino group make it a promising candidate for the synthesis of various pharmaceutical compounds.
Used in Organic Synthesis:
(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL is used as a precursor in the synthesis of other complex molecules. Its versatile structure allows it to be a key component in the creation of a wide range of organic compounds, making it valuable in the field of organic chemistry.
Used in Drug Development:
(1R,2R)-2-(PROPYLAMINO)CYCLOHEXANOL is used as a starting material in the development of new drugs. Its unique properties and reactivity make it a valuable asset in the design and synthesis of innovative pharmaceutical agents, potentially leading to the discovery of novel therapeutics.

InChI:InChI=1/C9H19NO/c1-2-7-10-8-5-3-4-6-9(8)11/h8-11H,2-7H2,1H3/t8-,9-/m1/s1

Upstream product

• 60093-74-5 trans-2-(propylamino)cyclohexan-1-ol 
• 107-10-8 propylamine 
• 286-20-4 cyclohexane-1,2-epoxide 

Downstream Products

• 60093-74-5 (1R)-trans-2-Propylamino-cyclohexanol-⁽¹⁾ 
• 60093-74-5 (1S)-trans-2-Propylamino-cyclohexanol-⁽¹⁾ 

Relevant academic research and scientific papers

Asymmetric amination of meso-epoxide with vegetable powder as a low-toxicity catalyst

This paper describes the scope and limitation of substrates subjected to asymmetric amination with epoxides catalyzed by a soluble soybean polysaccharide (Soyafibe S-DN), which we recently discovered from the reaction of 1,2-epoxycyclohexane with cyclopropylamine. Various meso-epoxides reacted with various amines afforded the corresponding products with good enantiomeric selectivity. Since it was found that pectin was found to have a catalytic ability after screening commercially available polysaccharides, we studied 33 different vegetable powders having pectic substances, and we found that many vegetable powders showed catalytic ability. These results should guide in using vegetable components as low-toxic catalysts for the production of pharmaceuticals.

Thieme chemistry journal awardees-where are they now? bifunctional organocatalysis with N-Formyl-l-proline: A novel approach to epoxide ring opening and sulfide oxidation

A conceptually distinct approach to the aminolysis of 1,2-epoxides, which involves Lewis base-Br?nsted acid catalysis employing N-formyl-l-proline as an easily accessible bifunctional organocatalyst and water as a solvent is presented. The potential of N-formyl-l-proline as organocatalyst for the sulfide oxidation reaction using aqueous hydrogen peroxide as environmentally benign and readily available oxidant is also demonstrated. Good to high yields are achieved for both reactions. Georg Thieme Verlag Stuttgart ? New York.

Synthesis of β-amino alcohols using MgO as a new catalyst under solvent-free conditions

MgO catalyzed efficiently the ring opening of epoxides with a range of aromatic and aliphatic amines to produce β-substituted alcohols in high yields under solvent-free conditions. Exclusive trans stereoselectivity is observed for cyclic epoxide.

FACILE AMINOLYSIS OF EPOXIDES WITH DIETHYLALUMINUM AMIDES

Treatment of an epoxide with a diethylaluminum amide in dichloromethane at room temperature affords the corresponding β-amino alcohol in good yield.