601-77-4

Usage

Uses

Used in Research and Development:
N-NITROSO-DI-ISO-PROPYLAMINE is used as a research chemical for studying the carcinogenic properties of nitroso compounds. Its application in this field aids scientists in understanding the mechanisms of carcinogenesis and developing potential countermeasures or treatments.
Used in Regulatory Compliance and Testing:
N-NITROSO-DI-ISO-PROPYLAMINE is utilized in regulatory compliance and testing to ensure the safety of consumer products and industrial materials. By testing for the presence of N-NITROSO-DI-ISO-PROPYLAMINE, industries can adhere to safety standards and protect the public from exposure to harmful substances.
Used in Environmental Monitoring:
N-NITROSO-DI-ISO-PROPYLAMINE is used in environmental monitoring to detect and quantify the presence of carcinogenic nitroso compounds in air, water, and soil. This helps in assessing the environmental impact of pollutants and implementing measures to mitigate their effects.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS and AMINES.

InChI:InChI=1/C6H14N2O/c1-5(2)8(7-9)6(3)4/h5-6H,1-4H3

Upstream product

• 543-67-9 n-propyl nitrite 
• 108-18-9 diisopropylamine 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 19009-39-3 N,N-diisopropylcarbamoyl chloride 
• 75-05-8 acetonitrile 
• 7782-77-6 cis-nitrous acid 
• 75-31-0 isopropylamine 

Downstream Products

• 921-14-2 N,N-diisopropylhydrazine 
• 4164-30-1 diisopropylnitramine 
• 3298-51-9 N,N-Diisopropyl-N'-formyl-hydrazin 
• 108-18-9 diisopropylamine 
• 88858-81-5 5-Nitro-2-hydroxy-benzal-diisopropylhydrazin 
• 112080-82-7 4-Nitrobenzaldehyd-diisopropylhydrazon 
• 128190-41-0 1-(4-Nitrophenyl)glyoxal-1-diisopropylhydrazon 
• 18481-95-3 1,1-diisopropyl-4-phenyl thiosemicarbazide 
• 36909-82-7 2-Benzolsulfonyl-1,1-diisopropyl-hydrazin 
• 13304-31-9 Tetra-isopropyl-2-tetrazen 

Relevant academic research and scientific papers

Reactivity of Nucleophilic Nitrogen Compounds towards the Nitroso Group

We discuss the reactivity of 43 nucleophilic nitrogen compounds towards the nitroso group of N-methyl-N-nitrosotoluene-p-sulfonamide (MNTS), and in some cases with alkyl nitrites.The series of nucleophiles considered is structurally very varied, includes members exhibiting the alpha effect, and covers 8 pKa units and a range of reactivities of almost five orders of magnitude.The values of solvent isotope effects and activation parameters have been measured and throw light on the structure of the transition states involved.Reactivities do not correlate well with thebasicity of the nucleophile, largely owing to the behaviour of primary amines, ammonia and nucleophiles with an alpha effect.Application of the curve crossing model suggests a relationship with vertical ionization potentials.The relationship with Ritchie's N+ scale is discussed, and interesting correlations with the reactivities of the same nucleophiles in various other chemical processes are noted.

Formation of Nitrosamines in Alkaline Conditions: a Kinetic Study of the Nitrosation of Linear and Cyclic Secondary Amines by Nitroalkanes

A study has been made of the nitrosation of sixteen secondary amines, six alkylamines (dimethylamine, diethylamine, dipropylamine, diisopropylamine, dibutylamine, diisobutylamine) and ten cyclic secondary amines (2-methylaziridine, azetidine, pyrrolidine, piperidine, 2-methylpiperidine, homopiperidine, heptamethyleneimine, piperazine, 1-methylpiperazine and morpholine) by nitropropane and nitrobutane in a strongly basic medium (-> = 0.1 mol dm-3).The nitrites were not formed in situ (i.e. in the actual bulk of the reaction medium) but rather were isolated,purified and used in pure form.The rate equation (i) was found v = k2obs (i).The fitting of the experimental results to the Taft correlation points to a nucleophilic attack on nitrite esters by the amines.Analysis of the log k2/pKa and log k2/Ei(v) correlations indicates orbital control of the reactions studied.These results, together with the fact that the reactivity of the different amines diminishes ostensibly when the values of the 13C-H nuclear spin coupling constant in the series of corresponding cycloalkanes increase, show that the overall hybridization of the nitrogen atom in the cycle changes from sp2 in the triangular nucleophile methylaziridine to sp3 in larger cycles.The results obtained at different temperatures and with water-tetrahydrofuran media, together with a study of isotope effects suggest that these reactions occur through a highly ordered transition state and that the role of solvation should not be overlooked.