601-77-4

Basic information

• Product Name: N-NITROSO-DI-ISO-PROPYLAMINE
• Synonyms: n-nitroso-diisopropylamin;N-Nitrosodi-i-propylamine;, N-isopropyl-N-nitroso-2-propanamine;1,1'-Dimethyl-N-nitrosodiethylamine;N-(1-Methylethyl)-N-nitroso-2-propanamine;NSC 336;Diisopropylnitrosoamine;N,N-di(propan-2-yl)nitrous amide
• CAS NO: 601-77-4
• Molecular Formula: C₆H₁₄N₂O
• Molecular Weight: 130.18816
• Product Categories: Nitrosamine;Mutagenesis Research Chemicals;Nitric Oxide Reagents
• Mol File: 601-77-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: >300°C
• Boiling Point: 194.5℃
• Flash Point: 73.6°C
• Appearance: /
• Density: 0.9422
• Vapor Pressure: 0.616mmHg at 25°C
• Refractive Index: 1.4431 (estimate)
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• PKA: -2.65±0.70(Predicted)
• Water Solubility: 13.02g/L(24 oC)
• CAS DataBase Reference: N-NITROSO-DI-ISO-PROPYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-NITROSO-DI-ISO-PROPYLAMINE(601-77-4)
• EPA Substance Registry System: N-NITROSO-DI-ISO-PROPYLAMINE(601-77-4)

Safety Data

• Statements: 22-45
• Safety Statements: 53
• RIDADR: 2811
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 601-77-4(Hazardous Substances Data)

Usage

Chemical Properties

Off-White to Pale Yellow Solid

Uses

Different sources of media describe the Uses of 601-77-4 differently. You can refer to the following data:
1. A nitroso compound that shows carcinogenic effect
2. N-Nitrosodiisopropylamine ia a nitrosoamine compound that shows carcinogenic effect.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also NNITROSO COMPOUNDS and AMINES.

InChI:InChI=1/C6H14N2O/c1-5(2)8(7-9)6(3)4/h5-6H,1-4H3

Upstream product

• 7782-77-6 cis-nitrous acid 
• 75-31-0 isopropylamine 
• 80-11-5 N-methyl-N-nitrosotoluene-p-sulfonamide 
• 108-18-9 diisopropylamine 
• 543-67-9 n-propyl nitrite 
• 19009-39-3 N,N-diisopropylcarbamoyl chloride 
• 75-05-8 acetonitrile 

Downstream Products

• 112080-82-7 4-Nitrobenzaldehyd-diisopropylhydrazon 
• 128190-41-0 1-(4-Nitrophenyl)glyoxal-1-diisopropylhydrazon 
• 18481-95-3 1,1-diisopropyl-4-phenyl thiosemicarbazide 
• 36909-82-7 2-Benzolsulfonyl-1,1-diisopropyl-hydrazin 
• 13304-31-9 Tetra-isopropyl-2-tetrazen 
• 88858-81-5 5-Nitro-2-hydroxy-benzal-diisopropylhydrazin 
• 921-14-2 N,N-diisopropylhydrazine 
• 108-18-9 diisopropylamine 
• 4164-30-1 diisopropylnitramine 
• 3298-51-9 N,N-Diisopropyl-N'-formyl-hydrazin 

Relevant articles and documents

Reactivity of Nucleophilic Nitrogen Compounds towards the Nitroso Group

We discuss the reactivity of 43 nucleophilic nitrogen compounds towards the nitroso group of N-methyl-N-nitrosotoluene-p-sulfonamide (MNTS), and in some cases with alkyl nitrites.The series of nucleophiles considered is structurally very varied, includes members exhibiting the alpha effect, and covers 8 pKa units and a range of reactivities of almost five orders of magnitude.The values of solvent isotope effects and activation parameters have been measured and throw light on the structure of the transition states involved.Reactivities do not correlate well with thebasicity of the nucleophile, largely owing to the behaviour of primary amines, ammonia and nucleophiles with an alpha effect.Application of the curve crossing model suggests a relationship with vertical ionization potentials.The relationship with Ritchie's N+ scale is discussed, and interesting correlations with the reactivities of the same nucleophiles in various other chemical processes are noted.